Influence of Preload Dependence on the Effect of Phenylephrine on Cardiac Output
The perioperative hemodynamic management aims to ensure organ perfusion pressure and an oxygen arterial transport adapted to oxygen consumption. Phenylephrine is the α-adrenergic agonist widely used during anesthesia for arterial pressure control.
Several questions on phenylephrine global and regional hemodynamics effects remain unresolved.
The investigators assume that Phenylephrine may decrease cardiac output by increasing the afterload, while most likely could also make an increase or a stability of cardiac output by action on the venous return. The investigators propose an observational study assessing the influence of preload dependence, defined by the values of pulse pressure variation, on the effect of phenylephrine on cardiac output, measured beat by beat by esophageal Doppler.
The aim of the investigators work is to improve the understanding of phenylephrine action, a daily use therapeutic action, to improve the patients care.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Influence of Preload Dependence on the Effect of Phenylephrine on Cardiac Output|
- cardiac output [ Time Frame: one year ] [ Designated as safety issue: No ]Comparing cardiac output values before and after injection of a phenylephrine bolus, based on the existence of a preload dependency, defined by a measure of respiratory variation of pulse pressure greater than or equal to 13%.
|Study Start Date:||November 2012|
|Estimated Study Completion Date:||January 2014|
|Estimated Primary Completion Date:||November 2013 (Final data collection date for primary outcome measure)|
|Contact: Olivier REBET, M.Dfirstname.lastname@example.org|
|Contact: Jean Luc FELLAHI, M.D;Ph.Demail@example.com|
|CAEN University Hospital||Recruiting|
|Caen, Basse Normandie, France, 1400|
|Contact: Olivier REBET, M.D +33611131751 firstname.lastname@example.org|
|Contact: Jean Luc FELLAHI, M.D;Ph.D email@example.com|
|Principal Investigator:||Olivier REBET, M.D||University Hospital, Caen|