Cerebellum - Cognitive Outcome and Functional Connectivity
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Purpose
Aim: To investigate the effect of cerebellar tumor surgery on the resting state functional connectivity level in higher order cognition networks known to interact with the cerebellum. Furthermore, to correlate the connectivity level of these networks with the neuropsychological performance and functional outcome of the patients.
The investigator's hypothesis is that the functional connectivity of various cognition networks in the cerebrum as assessed by resting-state functional magnetic resonance imaging can be impaired after cerebellar tumor surgery and can be correlated with the neuropsychological performance. The effect of surgery on the cognition networks and the neuropsychological performance is dependent on the tumor location within the cerebellum. Such a correlation seems feasible as functional connectivity analysis could be correlated with the neuropsychological impairment in various neuropsychiatric disorders. Furthermore, investigators were able to depict the maturation of the functional connectivity networks in parallel to the neurocognitive development in childhood
| Condition |
|---|
|
Childhood Cerebellar Tumor |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Cerebellar Tumors of Childhood - Impact on Cognition and Functional Connectivity |
- neuropsychological assessment [ Time Frame: up to 24 months ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 40 |
| Study Start Date: | January 2013 |
| Estimated Study Completion Date: | January 2015 |
| Estimated Primary Completion Date: | January 2015 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
patients
children operated on a cerebellar tumor
|
|
healthy subjects
healthy volunteers
|
Eligibility| Ages Eligible for Study: | 15 Years to 30 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
young adolescent operated on a cerebellar tumor as a child
Inclusion Criteria:
• Male or female patients aged > 15 yrs
- Age at surgery between 1 yrs - 12 yrs
- Compliance (the patients have to be able to lay motionless in a 3 Tesla MR scanner and to cooperate with the examiner during the examination)
- Signed informed consent from the patient and/or the parents
Exclusion Criteria:
• Patients with Neurofibromatosis 1
- Severe visual or auditory impairment
- Cerebrospinal fluid shunt device
- Prior radiotherapy or chemotherapy
- Contraindications to MRI
Contacts and Locations| Contact: Christian Dorfer, MD | 0043140400 ext 4560 | christian.dorfer@meduniwien.ac.at |
| Austria | |
| MUV, Department of Neurosurgery | Not yet recruiting |
| Vienna, Austria, 1090 | |
| Contact: Christian Dorfer, MD christian.dorfer@meduniwien.ac.at | |
| Principal Investigator: | Christian Dorfer, MD | MUV, Department of Neurosurgery |
More Information
No publications provided
| Responsible Party: | Christian Dorfer, Dr.med.univ., Medical University of Vienna |
| ClinicalTrials.gov Identifier: | NCT01730274 History of Changes |
| Other Study ID Numbers: | cerebellum 1.1, KLI 252 |
| Study First Received: | November 15, 2012 |
| Last Updated: | November 20, 2012 |
| Health Authority: | Austria: Agency for Health and Food Safety |
Additional relevant MeSH terms:
|
Cerebellar Diseases Cerebellar Neoplasms Infratentorial Neoplasms Brain Neoplasms Central Nervous System Neoplasms Nervous System Neoplasms |
Neoplasms by Site Neoplasms Brain Diseases Central Nervous System Diseases Nervous System Diseases |
ClinicalTrials.gov processed this record on June 13, 2013