To Study the Effect of Organic Light Emitting Diodes (OLED) on Cultured Fibroblast

This study is currently recruiting participants. (see Contacts and Locations)
Verified November 2012 by National Taiwan University Hospital
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT01724710
First received: August 28, 2012
Last updated: November 9, 2012
Last verified: November 2012
  Purpose

Chronic ulcers is a common clinical problem. Diabetes or peripheral vascular occlusion is major reason leading to chronic wound healing.

The investigators's previous animal experiments have confirmed that OLED can promote burn wound healing and fibroblast proliferation in normal Wistar rat.

In order to find the time point and dosage of the effective light therapy. The investigators further use cultured human fibroblasts in vitro to study light therapy to promote fibroblast proliferation mechanisms.

Expect clinical application of light therapy in the future is more accurate and effective.


Condition
Non-pressure Chronic Ulcer of Skin, Not Elsewhere Classified

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: To Study the Effect of Organic Light Emitting Diodes (OLED) on Cultured Fibroblast

Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   Samples With DNA

Fibroblasts of Chronic ulcer and normal skin will be cultured. Fibroblast culture will be analyzed with quantitative PCR.


Estimated Enrollment: 10
Study Start Date: August 2012
Estimated Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
chronic ulcer
1x1cm2 tissue from chronic ulcer wound
normal skin
1x1x0.1 cm3 normal skin from graft

Detailed Description:

Chronic ulcers is a common clinical problem. Diabetes or peripheral vascular occlusion is major reason leading to chronic wound healing.

Therapeutic methods to promote wound healing are hyperbaric oxygen therapy, vacuum assisted therapy and photostimulation.

Although there are many treatments but no one has been widely accepted. The clinical effects of uncertainty, high cost and inconvenience of use is the main reason.

Each year amputation of the population due to chronic ulcers has not decreased. In order to break the current medical difficulties, We refer to the new light therapy technology.

Look forward to shorten the healing time and reduce medicine costs. The investigators's previous animal experiments have confirmed that OLED can promote burn wound healing and fibroblast proliferation in normal Wistar rat.

In order to find the time point and dosage of the effective light therapy. The investigators further use cultured human fibroblasts in vitro to study light therapy to promote fibroblast proliferation mechanisms.

Expect clinical application of light therapy in the future is more accurate and effective irradiative time points and dosage.

  Eligibility

Ages Eligible for Study:   50 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
  1. The process of collecting chronic ulcer skin: When the patient accept wound debridement surgery, visiting staff will take 1x1cm2 skin of chronic ulcer.
  2. The process of collecting normal skin: When the patient accept skin-grafting surgery, visiting staff will take 1x1x0.1cm3 skin.
Criteria

Inclusion Criteria:

  • chronic ulcer
  • normal skin
  • age 50~80 years,
  • chronic skin ulcer patient
  • skin-grafting patient

Exclusion Criteria:

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01724710

Contacts
Contact: Kean Eng Yeong, college 886-2-23123456 ext 65648 smartpace88@hotmail.com

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Kean Eng Yeong, college    886-2-23123456 ext 65648    smartpace88@hotmail.com   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Study Chair: Kean Eng Yeong, college NTUH Burn lab
  More Information

No publications provided

Responsible Party: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT01724710     History of Changes
Other Study ID Numbers: 201206038RIC
Study First Received: August 28, 2012
Last Updated: November 9, 2012
Health Authority: Taiwan: Department of Health

Additional relevant MeSH terms:
Skin Ulcer
Chronic Disease
Skin Diseases
Disease Attributes
Pathologic Processes

ClinicalTrials.gov processed this record on August 28, 2014