Study Measuring Total Plasma Ropivacaine Levels During Continuous Peripheral Nerve Catheter Infusion
The purpose of the study is to measure the blood levels of the medicine called ropivacaine (local anesthetic) used to manage pain. Ropivacaine is a widely used medication and is not the subject of this study, but the investigators are studying how much of the drug can be found in the patient's blood, known as the blood level, of this medicine. Too much ropivacaine in a patient's blood can lead to local anesthetic toxicity. Once the nerve catheter is removed, local anesthetic toxicity is no longer a potential problem. However, there is little data on what ropivacaine blood levels are after having the catheter in for a long period of time(up to one month).
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Study Measuring Total Plasma Ropivacaine Levels During Continuous Peripheral Nerve Catheter Infusion|
- Plasma Ropivicaine Levels [ Time Frame: up to 10 days ] [ Designated as safety issue: No ]Blood will be drawn every 0, 3, 5, 7, and 10 days. Blood is drawn every 3 days thereafter.
Biospecimen Retention: Samples Without DNA
The plasma ropivacaine samples will be assayed at the Department of Research Programs Laboratory (DRP) at WRNMMC. Once the whole blood sample has been centrifuged, the plasma will be removed with a glass pipette, placed in a storage container. The blood samples will be labeled with a non sequential serial number and will not include the time of the blood draw. This will blind the DRP laboratory to the patient's identity and timing of the blood draw.
|Study Start Date:||April 2010|
|Study Completion Date:||November 2011|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01718262
|United States, Maryland|
|Walter Reed National Military Medical Center|
|Bethesda, Maryland, United States, 20889|