Comparing Diurnal Fluctuations in Intra Ocular Pressure Measured in Same Day Versus Different Days in Glaucoma Patients (IOP)
Glaucoma is one of the leading causes of blindness in the west. The disease caused by high intra ocular pressure (IOP) and characterized by damage to the optic nerve and gradual loss of visual field. Intra ocular pressure change during the day. To evaluate the efficiency of the therapy it is common to measure the intra ocular pressure at different times of the day. Most ophthalmologists admit the patient for one day at which intra ocular pressure is measured at different times. This method does not mimic the patient daily routine and may not reflect the true diurnal fluctuations.
For this reason some ophthalmologists measure the intra ocular pressure at different times and at different days. It is not known if both methods give similar diurnal curves.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Comparing Diurnal Fluctuations in Intra Ocular Pressure Measured in Same Day Versus Different Days in Glaucoma Patients|
- IOP at different times of the day at same day versus different times and different days [ Time Frame: 5 weeks ] [ Designated as safety issue: No ]measurements of intra ocular pressure at different times of the day at same day versus different times and different days.
|Study Start Date:||November 2012|
|Estimated Study Completion Date:||December 2014|
|Estimated Primary Completion Date:||November 2013 (Final data collection date for primary outcome measure)|
Glaucoma patients treated with eye drops to lower the IOP.
A study physician will install anesthetic eye drops and will color the eye drops film with fluorescein. Study physician will use tonometer to measure the intra ocular pressure in each eye. This is a standard procedure done in any ophthalmological examination. Each patient will undergo intraocular pressure examination at 8:00, 12:00 and 16:00.
In the first day intra ocular pressure will be measured at 8:00, 12:00 and 16:00, same day measurements. The day after intra ocular pressure will be measured at 8:00, two days after at 12:00 and three days after at 16:00. One month later the patient will undergo another serious of intra ocular pressure measurements.
In the first day intra ocular pressure will be measured at 8:00, 12:00 and 16:00, same day measurements. The day after intra ocular pressure will be measured at 8:00, two days after at 12:00 and three days after at 16:00.
The relationship between the two diurnal curves will be analyzed.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01709916
|Carmel Medical Center||Not yet recruiting|
|Haifa, Israel, 34362|
|Contact: Orna Geyer, MD 972-4-8250419 email@example.com|
|Contact: Shaul Sar, MD 972-4-8250706 ShaulSa2@clalit.org.il|
|Principal Investigator: Orna Geyer, MD|
|Sub-Investigator: Shaul Sar, MD|
|Principal Investigator:||Orna Geyer, MD||Carmel Medical Center|