Cycling, Air Pollution and Health (CAPaH)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of British Columbia
ClinicalTrials.gov Identifier:
NCT01708356
First received: October 9, 2012
Last updated: October 15, 2012
Last verified: October 2012
  Purpose

Introduction: Cycling is currently promoted at the municipal, provincial and national level as a form of active transportation that increases physical activity while at the same time reducing traffic congestion, traffic-related air pollution and greenhouse gas emissions. While at a population level the health benefits of exercise via cycling are estimated to substantially exceed any health impacts related to air pollution exposure and injuries from traffic accidents , cyclists are known to experience elevated exposures to traffic-related air pollutants. Combined with exposure to elevated concentrations of air pollutants, cyclists also are subject to substantially increased inhaled doses due to their level of exertion and consequently increased inhalation rate. Therefore, given that cyclists experience exposures to relatively high concentrations of traffic-related air pollutants and that their inhalation of these pollutants is increased, it is important to evaluate the potential health impacts of this scenario. Research on the potential health impacts related to exercise (cycling) and urban air pollution exposure can help inform public communication strategies related to air quality and its health impacts. In addition, as our previous work suggests substantial variability in air pollution exposures to cyclists that is related to the route type and the levels of traffic along cycling routes, there is potential for transportation planners to promote increased cycling by enhancing infrastructure while at the same time developing routes that also minimize exposure to air pollution. The cyclist population is also interested in information regarding the air pollution exposures and potential health impacts related to cycling.

The objective of this study is to investigate the relationship between traffic-related air pollution exposure, and respiratory and cardiovascular health impacts in commuting cyclists. Specifically, the investigators propose to:

  1. determine commuting cyclists' exposure to traffic-related air pollutants (PM 2.5, PM10, ultrafine particulate, black carbon) while cycling along two different bicycle routes in the city of Vancouver;
  2. estimate the pollutant dose received by each cyclist, and relate this to the health effects observed; and
  3. determine if there is a change in lung function, endothelial function, and C-reactive protein level related to the level of air pollution exposure and dose

Condition Intervention
Endothelial Dysfunction
Endothelial Function
Cardiovascular Physiological Phenomena
Behavioral: Cycling on a residential route

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Cycling, Air Pollution and Health

Resource links provided by NLM:


Further study details as provided by University of British Columbia:

Primary Outcome Measures:
  • Change in endothelial function, as measured by peripheral arterial tonometry (EndoPAT) score of reactive hyperemia index (RHI) [ Time Frame: Baseline (1 hour pre-expousre) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Change in lung function (using spirometry to assess lung function values) [ Time Frame: Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors ] [ Designated as safety issue: No ]

Other Outcome Measures:
  • Change in blood levels of C-reactive protein (a marker of systemic inflammation) [ Time Frame: Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors ] [ Designated as safety issue: No ]
  • Change in blood levels of Interleukin-6 (a marker of systemic inflammation) [ Time Frame: Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors ] [ Designated as safety issue: No ]
  • Change in blood levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG)(a marker of oxidative stress) [ Time Frame: Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors ] [ Designated as safety issue: No ]

Enrollment: 38
Study Start Date: June 2010
Study Completion Date: November 2011
Primary Completion Date: November 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Normal cycling
Cycling on a residential and downtown route (crossover design)
Behavioral: Cycling on a residential route

  Eligibility

Ages Eligible for Study:   19 Years to 39 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age 19- 39
  • male or female
  • able to bicycle comfortably on city streets for 1 hour

Exclusion Criteria:

  • Smokers of any substance (smoking more than 1x every 2 weeks)
  • Must be of height to safely ride a test bike (<5'2", >6'5" )
  • Diagnosed asthma or active allergy (hav fever) symptoms
  • Irregular menstrual cycle, pregnant, breastfeeding, non-monocyclic contraceptive medication or device
  • Taking medication for heart or lung condition
  • Answers yes to any questions on physical activity readiness questionnaire (PAR-Q)
  • requires pain medication daily
  • visual or hearing impairment that prevents safe cycling on streets with motor vehicles
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01708356

Locations
Canada, British Columbia
Air Pollution Exposure Lab, Vancouver General Hospital through the School of Population and Public Health, University of British Columbia
Vancouver, British Columbia, Canada, V6T 1Z3
Sponsors and Collaborators
University of British Columbia
Investigators
Principal Investigator: Michael Brauer, ScD The University of British Columbia
  More Information

No publications provided

Responsible Party: University of British Columbia
ClinicalTrials.gov Identifier: NCT01708356     History of Changes
Other Study ID Numbers: H10-00902, H1008-111481/001/XSB
Study First Received: October 9, 2012
Last Updated: October 15, 2012
Health Authority: Canada: Health Canada

Keywords provided by University of British Columbia:
Air Pollution
Particulate Matter
Exercise
Respiratory Rate
Inflammation
Oxidative Stress
Plethysmography

ClinicalTrials.gov processed this record on October 19, 2014