Polymorphids an mRNA Expression in Obese Genes
Fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (GBP).
Are there any difference in polymorphids and/or mRNA expression in genes significant for developing obesity, between normal weight and obese individuals, with or without diabetes typ 2 .
Are there any difference in polymorphids and/or mRNA expression in different types of fat tissue
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Polymorphids and mRNA Expression in Genes, Significant for Developing Obesity and Typ II Diabetes in Different Types/Localisations of Fat Tissue|
- Differences in polymorphids and/or mRNA expression in genes, significant for developing obesity and type 2 diabetes, between patients with normal weight and obesity [ Time Frame: approximatly 30 minutes after start of operation ] [ Designated as safety issue: No ]fat biopsy taken from abdomen, omenta and thigh at surgery
- Difference in polymorphids and/or mRNA expression in different types of fat tissue in patients with normal weight or obesity with or without diabetes type 2 [ Time Frame: approximatly 30 minutes after start of operation ] [ Designated as safety issue: No ]fat biopsy; abdomen, omenta and thigh taken at surgery
Biospecimen Retention: Samples With DNA
biopsys; Fat from oment, thigh and abdomen
|Study Start Date:||January 2010|
|Study Completion Date:||February 2013|
|Primary Completion Date:||February 2013 (Final data collection date for primary outcome measure)|
Type 2 Diabetes and BMI>35
Patients with type 2 diabetes and body mass index 35 or more.
Patients undergoing surgery, gastric bypass or cholecystectomy, without diabetes type 2 and body mass index 35 or more
Patients undergoing surgery, cholecystectomy or reflux, without type 2 diabetes and body mass index between 18-27
Please refer to this study by its ClinicalTrials.gov identifier: NCT01708083
|Stockholm, Stockholm County Council, Sweden, 116 91|
|Karolinska Institutet, CMM|
|Stockholm, Sweden, 171 76|
|Principal Investigator:||Anders Thorell, Ass. prof.||Karolinska Institutet|