Is There a Relationship Between Previous Exposure to General Anesthesia and the Development of Alzheimer´s Disease? (DEMA)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2012 by University Hospital, Linkoeping.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
Anna-Karin Strand, MD, University Hospital, Linkoeping
ClinicalTrials.gov Identifier:
NCT01695889
First received: September 27, 2012
Last updated: September 28, 2012
Last verified: September 2012
  Purpose

The purpose of this study is to compare exposure to general anesthesia between cases with a diagnosis of Alzheimer´s disease and controls without diagnosis, through studies of medical records. The investigators wish to explore if there is a relationship between exposure to general anesthesia and the development of Alzheimer´s disease.


Condition
Alzheimer´s Disease
General Anesthesia

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: A Case-control Study of Exposure to General Anesthesia and a Diagnosis of Alzheimer´s Disease Later in Life.

Resource links provided by NLM:


Further study details as provided by University Hospital, Linkoeping:

Primary Outcome Measures:
  • Exposure to general anesthesia [ Time Frame: Up to 20 years in retrospect ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Exposure to inhaled anesthetics [ Time Frame: Up to 20 years in retrospect ] [ Designated as safety issue: No ]

Estimated Enrollment: 500
Study Start Date: May 2012
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Cases from a regional Alzheimer´s disease record. Matched controls from the national population register.

Criteria

Inclusion Criteria:

  • Clinical diagnosis of Alzheimer´s disease
  • Previous exposure to anesthesia

Exclusion Criteria:

  • Inability to retrieve medical records
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01695889

Contacts
Contact: Anna-Karin Strand, MD anna-karin.strand@lio.se

Locations
Sweden
University Hospital Recruiting
Linkoping, Sweden, 58185
Sponsors and Collaborators
University Hospital, Linkoeping
Investigators
Study Chair: Christina Eintrei, professor University Hospital Linkoping
  More Information

No publications provided

Responsible Party: Anna-Karin Strand, MD, Specialist in Anaesthesiology and Intensive Care, University Hospital, Linkoeping
ClinicalTrials.gov Identifier: NCT01695889     History of Changes
Other Study ID Numbers: DEMA-1
Study First Received: September 27, 2012
Last Updated: September 28, 2012
Health Authority: Sweden: Regional Ethical Review Board
Sweden: The National Board of Health and Welfare

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on September 18, 2014