Pseudoexfoliation and Chronic Kidney Disease

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Leyla Niyaz, Corum State Hospital
ClinicalTrials.gov Identifier:
NCT01693744
First received: September 20, 2012
Last updated: September 24, 2012
Last verified: September 2012
  Purpose

Background: Pseudoexfoliation (PEX) is characterised by the deposition of fibrillar material in an eye structures and many other parts of the body including kidneys and blood vessels. As both PEX and chronic kidney disease (CKD) are associated with oxidative stress and endothelial dysfunction we studied if the risk of PEX was increased in patients with CKD.

Methods: Patients over age 40 with the diagnosis of CKD were included in the study. Chronic kidney disease was diagnosed as decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m². Study groups were arranged as group 1 consisting of HD receiving patients, group 2 consisting of stage 1-4 CKD patients and group 3 consisting of patients with normal kidney functions (control group). Demographic properties and the rate of PEX were evaluated and compaired between the groups.


Condition
Chronic Kidney Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Relationship Between Pseudoexfoliation and Chronic Kidney Disease

Resource links provided by NLM:


Further study details as provided by Corum State Hospital:

Primary Outcome Measures:
  • Prevalance of pseudoexfoliation in patients with chronic kidney disease [ Time Frame: 7 months ] [ Designated as safety issue: No ]

Enrollment: 358
Study Start Date: October 2011
Study Completion Date: April 2012
Groups/Cohorts
Dialysis patients
Patients with stage 5 chronic kidney disease undergoing haemodialysis
Chronic kidney disease patients
Stage 1-4 Chronic kidney disease patients
Control group
Patients with normal renal functions

  Eligibility

Ages Eligible for Study:   40 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Patients from nephrology clinic

Criteria

Inclusion Criteria:

  • All patients with chronic kidney disease stage 1-5

Exclusion Criteria:

  • History of eye trauma or surgery
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01693744

Locations
Turkey
Corum State Hospital
Corum, Turkey, 19000
Sponsors and Collaborators
Corum State Hospital
Investigators
Principal Investigator: Leyla Niyaz, M.D. Specialist in Ophthalmology
  More Information

No publications provided

Responsible Party: Leyla Niyaz, Ophthalmology Specialist, Corum State Hospital
ClinicalTrials.gov Identifier: NCT01693744     History of Changes
Other Study ID Numbers: LNiyaz
Study First Received: September 20, 2012
Last Updated: September 24, 2012
Health Authority: Turkey: Ethics Committee

Keywords provided by Corum State Hospital:
Pseudoexfoliation, chronic kidney disease

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency

ClinicalTrials.gov processed this record on August 21, 2014