Study on the Effect of Fish Oil and Appetite

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
AAstrup, University of Copenhagen
ClinicalTrials.gov Identifier:
NCT01692990
First received: May 14, 2012
Last updated: November 9, 2012
Last verified: September 2012
  Purpose

20 normal-weight healthy subjects (10 males, 10 females) were in two periods given 10 of 0.5-mL capsules/day of fish oil and soybean oil for 3 weeks. In the end of each period they were given a standard breakfast and asked to report their appetite on visual analogue scales (VAS) immediately before and after the meal. The results were analyzed in accordance with the paired design under consideration of both supplement sequence and gender.


Condition Intervention Phase
Obesity
Cachexia
Dietary Supplement: Fish oil
Phase 0

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Study on the Effect of Fish Oil and Appetite

Resource links provided by NLM:


Further study details as provided by University of Copenhagen:

Primary Outcome Measures:
  • Appetite and satiation [ Time Frame: October 7th - November 25th 2011 ] [ Designated as safety issue: No ]
    Appetite and satiation were measured by visual analogue scales (VAS), which assessed satiation, hunger, fullness and desire to eat. Each scale was 100 mm in length with words anchored at each end, expressing the most positive and negative rating of each category.


Secondary Outcome Measures:
  • Weight change [ Time Frame: October 7th - November 25th 2011 ] [ Designated as safety issue: No ]
    Body weight was measured on the same scale without shoes and wearing light clothing in the morning before breakfast.


Enrollment: 20
Study Start Date: October 2011
Study Completion Date: November 2011
Primary Completion Date: November 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Fish oil
5 g/d in 10 capsules, providing 3.5 g of long-chain n-3 fatty acids
Dietary Supplement: Fish oil
For 3 weeks 5 g/d in 10 capsules, providing 3.5 g long-chain n-3 fatty acids in the fish oil period. Cross-over between arms with 1 week of wash out
Placebo Comparator: Soy bean oil
5 g/d in 10 capsules
Dietary Supplement: Fish oil
For 3 weeks 5 g/d in 10 capsules, providing 3.5 g long-chain n-3 fatty acids in the fish oil period. Cross-over between arms with 1 week of wash out

Detailed Description:

In a randomized cross-over design, 20 normal-weight healthy subjects (10 males, 10 females) were given 10 of 0.5-mL capsules/day of fish oil and soybean oil for 3 weeks. In the end of each period they were given a standard breakfast and asked to report their appetite on visual analogue scales (VAS) immediately before and after the meal. The results were analyzed in accordance with the paired design under consideration of both supplement sequence and gender.

  Eligibility

Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Normal weight (18.5<BMI<25 kg/m2).
  • Healthy.

Exclusion Criteria:

  • Subjects taking medication that could influence appetite.
  • Subjects with special nutritional needs e.g. pregnant and lactating, seriously ill or old people.
  • Subjects that had had fish oil-supplements for four weeks prior to the intervention period.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01692990

Locations
Denmark
Department of Human Nutrition
Frederiksberg, Denmark, 1958
Sponsors and Collaborators
AAstrup
Investigators
Principal Investigator: Lotte Lauritzen, PhD Department of Human Nutrition
  More Information

No publications provided

Responsible Party: AAstrup, Associate Professore Lotte Lauritzen, University of Copenhagen
ClinicalTrials.gov Identifier: NCT01692990     History of Changes
Other Study ID Numbers: LL-spec1
Study First Received: May 14, 2012
Last Updated: November 9, 2012
Health Authority: Denmark: The Danish National Committee on Biomedical Research Ethics

Keywords provided by University of Copenhagen:
Appetite
Fish oil
Long-chain n-3 fatty acids

ClinicalTrials.gov processed this record on October 16, 2014