Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease

This study is currently recruiting participants.
Verified February 2014 by Region Skane
Sponsor:
Information provided by (Responsible Party):
Region Skane
ClinicalTrials.gov Identifier:
NCT01686984
First received: September 13, 2012
Last updated: March 4, 2014
Last verified: February 2014
  Purpose

The purpose of this study is to investigate how inspiratory flow pattern influences CO2 elimination in people without primary lung disease.

The hypothesis is that a long mean distribution time, caused by a long postinspiratory pause and high end-inspiratory flow, will promote CO2 exchange in the alveoli.


Condition Intervention
Pulmonary Gas Exchange
Carbon Dioxide
Other: Altered breath

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease

Resource links provided by NLM:


Further study details as provided by Region Skane:

Primary Outcome Measures:
  • Carbon dioxide elimination in a ventilator assisted breath. [ Time Frame: 30 minutes ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Blood CO2 concentration. [ Time Frame: 30 minutes ] [ Designated as safety issue: No ]

Estimated Enrollment: 10
Study Start Date: September 2012
Estimated Study Completion Date: December 2014
Estimated Primary Completion Date: September 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Altered breath
The group where the investigators alter the inspiratory and expiratory aspects of a ventilated breath.
Other: Altered breath

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • No known primary lung disease

Exclusion Criteria:

  • Primary lung disease
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01686984

Contacts
Contact: Gunnar Malmkvist, Med.Dr +4646-171035 gunnar.malmkvist@skane.se

Locations
Sweden
Division of Brain, Heart and Lungs, Neurosurgical Clinic, Skane University Hospital, Lund Recruiting
Lund, Skane, Sweden, 22185
Contact: Samuel Allvin, Med. Student    +46706607477    samuelallvin@gmail.com   
Sponsors and Collaborators
Region Skane
Investigators
Principal Investigator: Mikael Bodelsson, Professor Division of Anesthesia, Skane University Hospital, Lund, Sweden
  More Information

No publications provided

Responsible Party: Region Skane
ClinicalTrials.gov Identifier: NCT01686984     History of Changes
Other Study ID Numbers: 2012/381
Study First Received: September 13, 2012
Last Updated: March 4, 2014
Health Authority: Sweden: Swedish Medical Product Agency

Additional relevant MeSH terms:
Respiratory Aspiration
Lung Diseases
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms

ClinicalTrials.gov processed this record on April 16, 2014