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Free Fatty Acids: Short Exposure Study

This study is currently recruiting participants.
Verified May 2013 by Purdue University
Sponsor:
Information provided by (Responsible Party):
Richard Mattes, Purdue University
ClinicalTrials.gov Identifier:
NCT01686113
First received: September 12, 2012
Last updated: December 2, 2013
Last verified: May 2013
  Purpose

This study will examine whether or not short, daily exposures change a person's ability to detect free fatty acids in a solution by its taste. Repeated exposure should improve a person's ability to detect free fatty acids.


Condition Intervention
Hypogeusia
Other: NEFA
Other: Sucrose

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Official Title: Free Fatty Acids: Short Exposure Study

Resource links provided by NLM:


Further study details as provided by Purdue University:

Primary Outcome Measures:
  • NEFA detection threshold [ Time Frame: 10 days ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Hunger [ Time Frame: 2 days ] [ Designated as safety issue: No ]
    Visual analog scale assessment of hunger level prior to testing

  • BMI [ Time Frame: 1 day ] [ Designated as safety issue: No ]
  • Taste descriptor [ Time Frame: 10 days ] [ Designated as safety issue: No ]
    Description of NEFA taste by participant, e.g., sour, bitter, etc.


Estimated Enrollment: 100
Study Start Date: May 2012
Estimated Primary Completion Date: May 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: NEFA
Participants swish and spit 5 mL of an oleic acid solution everyday for 10 days.
Other: NEFA
Other Name: Oleic acid
Active Comparator: Control
Participants swish and spit 5 mL of sucrose solution everyday for 10 days.
Other: Sucrose

Detailed Description:

The possibility that humans can taste non-esterified fatty acids (NEFA) - so-called fat taste - is a relatively new area of research. Previous work suggests that subjects require an average of between two and three testing sessions of approximately an hour each before they can reliably detect NEFA, and the average number of visits to get the lowest threshold is six. Streamlining this process is of great interest to researchers who wish to test many people as quickly as possible. Other taste qualities, including umami and sweet, have shown improvement in detection sensitivity in subjects that have undergone ten second exposures to these taste qualities for 10 days upon subsequent re-testing. We seek to determine if the same improvements can be seen with fat taste.

  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • good health
  • available for multiple testing visits

Exclusion Criteria:

  • have participated in a fat taste study in the past 6 months
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01686113

Contacts
Contact: Richard D Mattes, PhD 765--494-0662 mattes@purdue.edu

Locations
United States, Indiana
Purdue University Recruiting
West Lafayette, Indiana, United States, 47907
Contact: Richard D Mattes, PhD       mattes@purdue.edu   
Principal Investigator: Richard D Mattes, PhD, MPH, RD         
Sponsors and Collaborators
Purdue University
Investigators
Principal Investigator: Richard D Mattes, PhD Purdue University
  More Information

No publications provided

Responsible Party: Richard Mattes, Distinguished Prof Foods and Nutrition, Purdue University
ClinicalTrials.gov Identifier: NCT01686113     History of Changes
Other Study ID Numbers: 1205012317
Study First Received: September 12, 2012
Last Updated: December 2, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by Purdue University:
Taste
Fat Taste
Threshold Testing

Additional relevant MeSH terms:
Ageusia
Taste Disorders
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on April 16, 2014