Impact of Cooking Process on Meat Protein Digestion and Metabolism

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2012 by Institut National de la Recherche Agronomique.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
National Research Agency, France
Information provided by (Responsible Party):
Robert Benamouzig, Assistance Publique - Hôpitaux de Paris
ClinicalTrials.gov Identifier:
NCT01685307
First received: March 21, 2012
Last updated: September 11, 2012
Last verified: September 2012
  Purpose

Few is known on meat protein digestibility in humans and the impact of cooking process, while excessive intake of processed meat has been suggested to increase the risk of colorectal cancer.

This study aims to measure in vivo in humans the real digestibility of beef meat proteins depending 2 cooking processes, using ileal tubes and stable isotopes.


Condition Intervention
Physiology
Digestive Tract
Heating Process
Dietary Supplement: Test meal

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science

Further study details as provided by Institut National de la Recherche Agronomique:

Primary Outcome Measures:
  • protein digestibility [ Time Frame: single measure ] [ Designated as safety issue: No ]
    From ileal recovery of the ingested tracer during 8 h after the meal


Secondary Outcome Measures:
  • nitrogen metabolism [ Time Frame: single measure ] [ Designated as safety issue: No ]
    Distribution of dietary nitrogen throug metabolic pools


Estimated Enrollment: 48
Study Start Date: February 2012
Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: intense cooking process
Test meal: 150g of beef cooked at intense temperature. Beef proteins are intrinsically labelled with 15 N protein
Dietary Supplement: Test meal
test meal is 150 g of beef cooked either at moderate or high intensity. Proteins are intrinsically labelled with 15N.
Experimental: mild cooking process
Test meal: 150 g of beef cooked at moderate intensity. Beef proteins are intrinsically labeled with 15N.
Dietary Supplement: Test meal
test meal is 150 g of beef cooked either at moderate or high intensity. Proteins are intrinsically labelled with 15N.

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy
  • BMI between 18 an 27
  • Age between 18 and 45 years

Exclusion Criteria:

  • Gastrointestinal or liver pathology
  • Diabetes
  • Pregnancy
  • Vegetarian
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01685307

Contacts
Contact: Gheorghe Airinei, MD 33 1 48 95 74 30 gheorghe.airinei@avc.aphp.fr

Locations
France
Centre de Recherche sur volontaires Recruiting
Bobigny, France, 93
Contact: Gheorghe Airinei    33 1 48 95 53 34    gheorghe.airinei@avc.aphp.fr   
Principal Investigator: Robert Benamouzig, MD, PhD         
Sponsors and Collaborators
Institut National de la Recherche Agronomique
National Research Agency, France
Investigators
Study Director: Claire Gaudichon, PhD INRA AgroParisTech
  More Information

No publications provided

Responsible Party: Robert Benamouzig, Manager of the HNRC, Assistance Publique - Hôpitaux de Paris
ClinicalTrials.gov Identifier: NCT01685307     History of Changes
Other Study ID Numbers: PRONUTRIAL
Study First Received: March 21, 2012
Last Updated: September 11, 2012
Health Authority: France: Ministry of Health

Keywords provided by Institut National de la Recherche Agronomique:
ileal digestibility
metabolism
stable isotopes

ClinicalTrials.gov processed this record on September 18, 2014