Immature Myeloid Cells in Respiratory Syncytial Virus Bronchioliltis

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified September 2012 by Hillel Yaffe Medical Center
Sponsor:
Information provided by (Responsible Party):
Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier:
NCT01684527
First received: September 5, 2012
Last updated: September 10, 2012
Last verified: September 2012
  Purpose

The investigators hypothesize that Respiratory Syncytial Virus (RSV) infection may influence the population of lung immature myeloid cells and dendritic cells in a way that will impair their ability to invoke an effective immune response and lead to prolonged inflammation, angiogenesis and scarring. This may lead in turn to disturbed lung function.

Our aim is to determine the presence and phenotype of immature myeloid cells present in respiratory secretions of children with RSV bronchiolitis as compared to non-RSV bronchiolitis and healthy controls.


Condition Intervention
Bronchiolitis
Other: Respiratory secretions obtained

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Further study details as provided by Hillel Yaffe Medical Center:

Primary Outcome Measures:
  • Number of Immature Myeloid Cells in Respiratory Secretions [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of one week ] [ Designated as safety issue: No ]
    Respiratory secretions obtained from child presenting with bronchiolitis will be examined for the presence of immature myeloid cells


Estimated Enrollment: 55
Study Start Date: October 2012
Estimated Study Completion Date: January 2014
Estimated Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Children Suffering From Bronchiolitis
Respiratory secretions obtained from children suffering from Bronchiolitis
Other: Respiratory secretions obtained
Healthy Children
Respiratory secretions obtained from children with no respiratory infection
Other: Respiratory secretions obtained

  Eligibility

Ages Eligible for Study:   up to 2 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Children presenting in our pediatric department suffering from bronchiolitis

Criteria

Inclusion Criteria:

  • Bronchiolitis

Exclusion Criteria:

  • Chronic disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01684527

Locations
Israel
Hillel Yaffe Medical Center Not yet recruiting
Hadera, Israel, 38100
Contact: Vered Nir, MD    972-4-630-4331    verednr@yahoo.com   
Principal Investigator: Vered Nir, MD         
Sponsors and Collaborators
Hillel Yaffe Medical Center
  More Information

No publications provided

Responsible Party: Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier: NCT01684527     History of Changes
Other Study ID Numbers: 0039-12-HYMC
Study First Received: September 5, 2012
Last Updated: September 10, 2012
Health Authority: Israel: Ministry of Health

Additional relevant MeSH terms:
Bronchiolitis
Bronchitis
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Tract Infections

ClinicalTrials.gov processed this record on July 24, 2014