Obesity-related Genes in Taiwanese Undergoing Weight Loss

This study has been completed.
Sponsor:
Collaborator:
National Science Council, Taiwan
Information provided by (Responsible Party):
Sung Ling Yeh, Taipei Medical University Hospital
ClinicalTrials.gov Identifier:
NCT01684280
First received: September 10, 2012
Last updated: September 11, 2012
Last verified: September 2012
  Purpose

To investigate:

  1. Associations between miRNA and insulin signaling-related gene expressions in abdominal adipose tissues in obese subjects.
  2. Differences in miRNAs expressed by intrabdominal omental adipose tissues between genders.

Condition Intervention
Morbid Obesity
Genetic: gender

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Searching for the Most Influential Obesity-related Diabetic Genes and Exploring the Expression Profiles of Those Genes in Taiwanese Undergoing Weight Loss

Resource links provided by NLM:


Further study details as provided by Taipei Medical University Hospital:

Primary Outcome Measures:
  • MicroRNA expression in abdominal omental adipose tissues [ Time Frame: up to 28 weeks ] [ Designated as safety issue: Yes ]
    MicroRNA-125a-3p expression in abdominal omental adipose tissues is associated with insulin signaling-related gene expression levels in morbid obesity


Biospecimen Retention:   None Retained

Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent laparoscopic bariatric surgery.


Enrollment: 20
Study Start Date: June 2010
Study Completion Date: September 2010
Primary Completion Date: September 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
gender
Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery.
Genetic: gender
Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery.
Other Name: BMI were all over 40 kg/ m2

Detailed Description:

Compared the differences in microRNA expressions of abdominal adipose tissue in morbid obese male and female subjects to elucidate the possible regulatory role of microRNA in insulin signaling-related gene expression levels and its association with biochemical markers. We hope to find a miRNA that can be used to predict the syndrome associated with obesity.

  Eligibility

Ages Eligible for Study:   19 Years to 63 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men (n = 9) and women (n =10) who underwent bariatric surgery. Their BMI were all over 40 kg/ m2, and ages between 19-63 years.

Criteria

Inclusion Criteria:

  • Morbid obesity,BMIs> 40 kg/m2
  • Subjects who underwent bariatric surgery

Exclusion Criteria:

  • Obese subjects with complicated metabolic disorders
  • Thyroid disease
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01684280

Locations
Taiwan
Taipei Medical University Hospital
Taipei, Taiwan, 110
Sponsors and Collaborators
Sung Ling Yeh
National Science Council, Taiwan
Investigators
Study Director: Wang Weu Comprehensive Weight Management Center Taipei Medical University Hospital
  More Information

Additional Information:
Publications:

Responsible Party: Sung Ling Yeh, professor, Taipei Medical University Hospital
ClinicalTrials.gov Identifier: NCT01684280     History of Changes
Other Study ID Numbers: CRC-06-09-10
Study First Received: September 10, 2012
Last Updated: September 11, 2012
Health Authority: Taiwan: Department of Health

Keywords provided by Taipei Medical University Hospital:
abdominal adipose tissue; microRNA

Additional relevant MeSH terms:
Obesity
Obesity, Morbid
Weight Loss
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms
Body Weight Changes

ClinicalTrials.gov processed this record on July 26, 2014