Effect of High-calcium Intake on Appetite, Insulinemia and Incretins
The purpose of this study is to investigate the appetite, insulin and incretin hormone responses to a high-calcium meal.
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
|Official Title:||Effect of High-calcium Intake on Appetite, Insulinemia and Incretins|
- Subjective appetite ratings [ Time Frame: 3 hour ] [ Designated as safety issue: No ]Subjective ratings of appetite assessed by visual analogue scales.
- Serum insulin concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]2 hour area under the curve for serum insulin following breakfast consumption
- Plasma glucose-dependent insulinotropic peptide concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]2 hour area under the curve for plasma glucose-dependent insulinotropic peptide following breakfast consumption
- Plasma glucagon-like peptide-1 concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]2 hour area under the curve for plasma glucagon-like peptide-1 following breakfast consumption
- Total fat oxidised during 60 min of exercise (g) [ Time Frame: 1 hour ] [ Designated as safety issue: No ]Assessed by indirect calorimetry
|Study Start Date:||May 2012|
|Study Completion Date:||August 2012|
|Primary Completion Date:||August 2012 (Final data collection date for primary outcome measure)|
Placebo Comparator: Placebo
Breakfast consisting of milk-based porridge with a normal calcium content.
As control, but with a high-calcium content.
Dietary Supplement: Calcium
Participants will be provided with control and high-calcium meals. Insulin, appetite, glucagon-like peptide-1 and glucose-dependent insulinotropic peptide responses will be assessed, along with rates of substrate oxidation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01682343
|Newcastle upon Tyne, Tyne on Wear, United Kingdom, NE1 8ST|
|Principal Investigator:||Javier T Gonzalez, MRes||Northumbria University|