Epigenomic Dysregulation in Preeclampsia-Associated Chronic Hypertension
Preliminary data from the investigator's lab identified novel patterns of differential DNA methylation in genes regulating cardiovascular and metabolic function in blood from women during the first trimester of pregnancy who were destined to develop preeclampsia (PE) in the third trimester. Further, common patterns of differential DNA methylation were found in the common genes from placental tissue at time of birth in the same women after diagnosis with PE, suggesting that the epigenomic patterns that predict pregnancy-induced hypertension may also underlie the development of chronic hypertension years after.
It is unknown whether aberrant DNA methylation in pregnancy-induced hypertension is the mechanism by which chronic hypertension develops in these women remote from pregnancy nor is it known if hypertension remote from PE is as responsive to therapeutic treatment of hypertension compared to women who develop hypertension without history of PE. The investigators plan to objectively test the central hypothesis and attain the objective of this project
Pregnancy Induced Hypertension
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Observational Study of Epigenomic Dysregulation in Preeclampsia-Associated Chronic Hypertension|
- DNA methylation pattern [ Time Frame: age 30-65 ] [ Designated as safety issue: No ]Determine DNA methylatiion patterns in women with hypertension who have/have not had a prior diagnosis of preeclampsia
- Vascular function [ Time Frame: aged 30-65 ] [ Designated as safety issue: No ]Determine differences in vascular function among women aged 30-65, diagnosed with hypertension and who have/have not had a prior diagnosis of preeclampsia
Biospecimen Retention: Samples With DNA
Sputum and peripheral blood will be collected for DNA extraction and epigenetic analyses.
|Study Start Date:||May 2012|
|Estimated Primary Completion Date:||March 2014 (Final data collection date for primary outcome measure)|
History of Preeclampsia
Chronic hypertension with history of preeclampsia Chronic hypertension without history of preeclampsia