A Long-term Observational Study on the Efficacy of SSRIs Pharmacotherapy or Combined Treatment(SSRIs Pharmacotherapy + CBT) in Panic Disorder Patients
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Purpose
Fearful feelings as a kind of a very common anxiety disorder panic disorder unexpected severe anxiety attacks and autonomic nervous system symptoms and psychological symptoms seem to die for fear of lost control for themselves or accompanying diseases. The lifetime prevalence of panic disorder in most of the country, about 1.5-5% or so are known. As a result the other hand, more than half of patients with panic disorder from work or social life, family life, causing serious disruption to the quality of life decline significantly, frequent emergency room visits and medical tests due to a serious disease disease caused by the very large costs of Health and Social be It is known that the treatment of panic disorder with medication and psychotherapy are both effective. Representative as a treatment for panic disorder, Selective serotonin reuptake inhibitors (SSRIs) are recommended as first-line treatment of panic disorder. In general, the initial reaction rate of panic disorder medication known to be frequently stopped early recurrence 70-80% It's too early, it is recommended that the duration of drug treatment for at least one year to be long-lasting. But whether it is appropriate for the duration of drug treatment to maintain a certain extent remains controversial, and maintain the medication for more than one year, even if the long-term effects known to be approximately 50% less than beyond being negative when remission based. Meanwhile, the typical method for the treatment of panic disorder psychology, cognitive behavioral therapy (Cognitive behavioral therapy) and looked comparable to the effect of the drug in the treatment of the known, especially in recent years when the combined treatment with medication can increase the long-term treatment of sexual reported that there's has been the subject of attention.
But prospectively compare the long-term effects of these two treatments, research, especially the research about the long-term effects of the combined treatment with the drug treatment of panic disorder is very low, and almost nil is Researchers, drug treatment and the effect of the combined treatment in patients with panic disorder over two years prospective study to compare the plans were. And verification, the researchers performed only through this study by comparing the long-term effects of the combined treatment with medication combined treatment of medication to be more effective than if the reaction to the long-term treatment of panic disorder that can affect the clinical and biological factors navigate to evaluate them. In addition, long-term observational study, panic disorder patients' subjective quality of life actually improved to some extent on the map together proven to.
| Condition |
|---|
|
Panic Disorder |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
whole blood
| Estimated Enrollment: | 110 |
| Study Start Date: | February 2012 |
Show Detailed Description
Eligibility| Ages Eligible for Study: | 20 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Panic disorder patients 20 years of age or older to visit the Samsung Seoul Hospital, and the Department of Mental Health, a foreign patients, patients who agreed to participate in this study will be of. Plan the patient-specific total of 110 patients on each drug treatment group and combined treatment group, 55 patients recruited by the first year of study commences 2 years F / U to enforce the number of subjects. Which G * Power 3.0.10 version program (Erdfelder, E., Faul, F., & Buchner, A. (1996)), using the power 80%, significance level of 5%, effect size 0.6, and the case and control groups equal number allocation to treatment in panic disorder seems common rate, the percentage of Asian American about 20% and Samsung Seoul hospital, Department of mental Health, panic disorder patients for many years to visit when you consider that approximately 2,300 (initial 200 patients, at least), the appropriate is suggested by the number of subjects.
Inclusion Criteria:
- Outpatients with panic disorder at the SMC
- PD patients who agree to participate in the clinical study
- PD patients who are over 20 years old
Exclusion Criteria:
- PD patients who have either severe medical illnesses or other psychiatric illnesses
- PD patients who are pregnant, or lactating
- PD patients who have suicidal idea
Contacts and Locations
More Information
No publications provided
| Responsible Party: | Samsung Medical Center |
| ClinicalTrials.gov Identifier: | NCT01674673 History of Changes |
| Other Study ID Numbers: | 2011-10-130 |
| Study First Received: | August 24, 2012 |
| Last Updated: | August 24, 2012 |
| Health Authority: | United States: Food and Drug Administration |
Keywords provided by Samsung Medical Center:
|
panic disorder SSRIs pharmacotherapy Cognitive Behavioral therapy |
Additional relevant MeSH terms:
|
Panic Disorder Anxiety Disorders Mental Disorders |
ClinicalTrials.gov processed this record on May 16, 2013