Stair Descending vs. Stair Ascending Exercise

This study has been completed.
Sponsor:
Collaborators:
University of Thessaly
Aristotle University Of Thessaloniki
Information provided by (Responsible Party):
Dr. Anastasios Theodorou, European University Cyprus
ClinicalTrials.gov Identifier:
NCT01673958
First received: August 22, 2012
Last updated: August 24, 2012
Last verified: August 2012
  Purpose

The aim of the present project is to compare the acute and chronic effect of stair descending versus stair ascending exercise on muscle damage and performance in elderly males with chronic heart failure.


Condition Intervention
Aging
Heart Failure
Sarcopenia
Other: Exercise

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: The Effect of Stair Descending and Stair Ascending Exercise on Muscle Strength and Performance: the SmartEscalator Device

Resource links provided by NLM:


Further study details as provided by European University Cyprus:

Primary Outcome Measures:
  • Muscle strength (torque) [ Time Frame: Change from baseline in muscle strength at day 2 post exercise at the first and sixth week of training ] [ Designated as safety issue: No ]
    An isokinetic dynamometer (Cybex, Ronkonkoma, NY) will be used for the measurement of isometric, eccentric and concentric knee extensor peak torque at 90° knee flexion. The average of the three best maximal voluntary contractions with their dominant leg will be recorded. In order to ensure that the subjects provide their maximal effort, the measurements will be repeated if the difference between the lower and the higher torque value exceeded 10%. There will be two minutes rest between isometric efforts.


Secondary Outcome Measures:
  • Pain free range of motion (degrees) [ Time Frame: Before and at day 2 post exercise at the first and sixth week of training ] [ Designated as safety issue: No ]
    The assessment of pain-free ROM will be performed manually using the the isokinetic dynamometer. The investigator will move the calf at a very low angular velocity from 0 knee extension to the position where the subject will feel any discomfort.

  • Creatine kinase, CK (activity IU) [ Time Frame: Before and at day 2 post exercise at the first and sixth week of training ] [ Designated as safety issue: No ]
    CK activity will be measured as a general indicator of muscle damage.It will be measured in a Cobas Integra Plus 400 chemistry analyzer.

  • Delayed onset muscle soreness, DOMS (scale 1-10) [ Time Frame: Before and at day 2 post exercise at the first and sixth week of training ] [ Designated as safety issue: No ]
    Each participant will assess delayed onset muscle soreness (DOMS) during squat movement (90o knee flexion) and perceived soreness will be rated on a scale ranging from 1 (normal) to 10 (very sore).


Enrollment: 12
Study Start Date: February 2012
Study Completion Date: April 2012
Primary Completion Date: April 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Stair descending group
Stair descending exercise. Participants will carry out six weeks of stair descending training consisting of three exercise sessions per week.
Other: Exercise
Comparison between stair descending and stair ascending training
Experimental: Stair ascending group
Stair ascending exercise. Participants will carry out six weeks of stair descending training consisting of three exercise sessions per week.
Other: Exercise
Comparison between stair descending and stair ascending training

Detailed Description:

Study design:

Twelve elderly males with chronic heart failure, New York Heart Association class I-II, will participate in this study. Participants will be allocated into two equally-sized groups: a stair descending group (n = 6) and a stair ascending group (n = 6). At the beginning of the study, the volunteers will perform an acute bout of stair descending or stair ascending exercise on an automatic escalator (4 sets of 3 min each, speed will be set at 45 steps∙min-1). Step height will be 20.5 mm. Before and at day 2 post exercise, physiologic measurements will be performed and blood samples will be collected. Then, participants will carry out six weeks of stair descending or ascending training consisting of three exercise sessions per week (the first two weeks the speed will be set at 45 steps∙min-1, the next two weeks at 50 steps∙min-1 and the last two weeks at 55 steps∙min-1 for both groups). Afterward, they will repeat the acute stair descending or ascending protocol, as carried out at the beginning of the study, and the same physiologic measurements will be performed and blood samples will be collected.

Measurements:

Isometric (at 90 knee flexion), concentric and eccentric peak torque at 60o∙s-1of quadriceps femoris, pain-free range of motion, delayed onset muscle soreness and creatine kinase will be measured.

  Eligibility

Ages Eligible for Study:   60 Years to 70 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • chronic heart failure (New York Heart Association class I-II)
  • subject provides written informed consent
  • personal physician of the participants provides written informed consent

Exclusion Criteria:

  • smoker
  • consumed any nutritional supplement the last 3 months
  • performed intense eccentric exercise the last 6 months
  • non Caucasian
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01673958

Locations
Cyprus
European University Cyprus
Nicosia, Cyprus, 1516
Sponsors and Collaborators
European University Cyprus
University of Thessaly
Aristotle University Of Thessaloniki
Investigators
Study Chair: George Panayiotou, PhD Research Centre, European University Cyprus
  More Information

Publications:
Responsible Party: Dr. Anastasios Theodorou, Principal investigator, European University Cyprus
ClinicalTrials.gov Identifier: NCT01673958     History of Changes
Other Study ID Numbers: EUC-011
Study First Received: August 22, 2012
Last Updated: August 24, 2012
Health Authority: Cyprus: Ministry of Health

Keywords provided by European University Cyprus:
Eccentric exercise
Aging
Heart failure
Muscle strength loss
Sarcopenia

Additional relevant MeSH terms:
Heart Failure
Sarcopenia
Heart Diseases
Cardiovascular Diseases
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Atrophy
Pathological Conditions, Anatomical
Signs and Symptoms

ClinicalTrials.gov processed this record on July 23, 2014