Oxytocin Antagonist in Patients With Repeated Failure of Implantation
In this study the investigators compare the usual way of embryo transfer (without medication) with an embryo transfer while administering oxytocine antagonist. This to improve implantation and increase the pregnancy rate.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver)
Primary Purpose: Treatment
|Official Title:||Oxytocin Antagonist in Patients With Repeated Failure of Implantation. A Prospective Randomized Placebo-controlled Double-blind Study.|
- implantation rate [ Time Frame: 16 days from eggretrieval ] [ Designated as safety issue: No ]the number of patients that show a positive blood pregnancy test
- pregnancy rate [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]The number of patients with an ongoing first trimester pregnancy
|Study Start Date:||February 2012|
|Estimated Primary Completion Date:||February 2014 (Final data collection date for primary outcome measure)|
Active Comparator: Atosiban
Patients receive a bolus injection of 6.75mg atosiban and following an atosibaninfusion at 18mg/u during 3 hours.
Bolus atosiban 6.75mg + infusion atosiban 18mg/u during 3 hours. once administered starting 1 hour before embryotransfer.
Placebo Comparator: placebo
Patients receive a placebo bolus injection (NaCl 0.9%)and an infusion of NaCl 0.9% during 3 hours
|Contact: Wim Decleer, gynecologist||0032 9 firstname.lastname@example.org|
|Contact: Paul Devroey, professor||0032 9 email@example.com|
|AZ Jan Palfijn||Recruiting|
|Gent, Oost-vlaanderen, Belgium, 9000|
|Contact: Wim Decleer, gynecologist 0032 9 2243024 firstname.lastname@example.org|
|Contact 0032 9 2248850 email@example.com|
|Principal Investigator: Wim Decleer, gynecologist|