Social Network Interventions in Rural Honduras

This study is enrolling participants by invitation only.
Sponsor:
Collaborator:
Yale University
Information provided by (Responsible Party):
Thomas Keegan, Ph.D., Yale University
ClinicalTrials.gov Identifier:
NCT01672580
First received: August 20, 2012
Last updated: January 24, 2014
Last verified: January 2014
  Purpose

This project will examine the spread of health interventions with a randomized control trial design by introducing public health interventions in 32 villages in the Honduran Department of Lempira. Based on identified public health needs in the region, namely improved drinking water and diet, this study will provide training on the use of chlorine (sodium hypochlorite) for water purification and multivitamins for nutritional supplementation. In some villages, individuals selected for their social connectedness will be trained and given coupons that can be redeemed for either chlorine bleach or multivitamins, and these persons will be asked to spread this information and distribute coupons to four people of their choosing. In other villages, individuals selected at random will receive the same training, materials, and instructions. A second wave of coupon distribution will provide coupons to those who received a coupon from the original "seed" groups so that they may disperse these coupons further out in the social networks. Over the following months, study investigators will look at how knowledge of these health practices, and uptake or and adherence to the practices, spreads throughout the villages.

More specifically, the investigators will examine the speed and extent of spreading of these new health practices after introducing them to three different initial "seed" groups: (1) people chosen on the basis of being named as a friend by many people in their village, (2) people chosen based on being named as a friend by a randomly chosen individual, and (3) a group of randomly chosen individuals. It is hypothesized that spread will occur faster and/or to a greater extent when the intervention is started in groups 1 and 2 versus group 3 (control group).


Condition Intervention
Malnutrition
Dysentery
Social Transmission of Health Behaviors
Behavioral: exposure to vitamin use
Behavioral: exposure to water chlorination
Behavioral: high in-degree
Behavioral: nominated by random

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Official Title: Diffusion of Health Interventions Across Social Networks in Honduran Villages

Resource links provided by NLM:


Further study details as provided by Harvard University:

Primary Outcome Measures:
  • Intervention Spread [ Time Frame: October 2012 ] [ Designated as safety issue: No ]
    Use of health product among community members will be tracked.


Estimated Enrollment: 4500
Study Start Date: August 2012
Estimated Study Completion Date: October 2014
Primary Completion Date: October 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Random-Cloro
exposure to water chlorination
Behavioral: exposure to water chlorination
"Seed" individuals in village are given Clorox bleach for water purification, with training on use and general information on water hygiene, along with coupons to distribute to others in village
Other Name: Clorox
Active Comparator: Random-Vitamin
exposure to vitamin use
Behavioral: exposure to vitamin use
"Seed" individuals in village are given daily adult multivitamin, with training on use and general nutrition information, along with coupons to distribute to others in village
Other Name: Medox Forte
Experimental: Indegree-Cloro
high in-degree, exposure to water chlorination
Behavioral: exposure to water chlorination
"Seed" individuals in village are given Clorox bleach for water purification, with training on use and general information on water hygiene, along with coupons to distribute to others in village
Other Name: Clorox
Behavioral: high in-degree
"Seed" individuals for starting intervention are chosen on the basis of high (social network) in-degree
Experimental: Indegree-Vitamin
high in-degree, exposure to vitamin use
Behavioral: exposure to vitamin use
"Seed" individuals in village are given daily adult multivitamin, with training on use and general nutrition information, along with coupons to distribute to others in village
Other Name: Medox Forte
Behavioral: high in-degree
"Seed" individuals for starting intervention are chosen on the basis of high (social network) in-degree
Experimental: Nominated-Cloro
nominated by random, exposure to water chlorination
Behavioral: exposure to water chlorination
"Seed" individuals in village are given Clorox bleach for water purification, with training on use and general information on water hygiene, along with coupons to distribute to others in village
Other Name: Clorox
Behavioral: nominated by random
"Seed" individuals for starting intervention are chosen on the basis of being named as a friend/alter of a randomly selected individual
Experimental: Nominated-Vitamin
nominated by random, exposure to vitamin use
Behavioral: exposure to vitamin use
"Seed" individuals in village are given daily adult multivitamin, with training on use and general nutrition information, along with coupons to distribute to others in village
Other Name: Medox Forte
Behavioral: nominated by random
"Seed" individuals for starting intervention are chosen on the basis of being named as a friend/alter of a randomly selected individual

  Eligibility

Ages Eligible for Study:   15 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Residents of Targeted Communities, ages 15 and up

Exclusion Criteria:

  • Children younger than age 15
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01672580

Locations
United States, Connecticut
Yale University
New Haven, Connecticut, United States, 06517
Sponsors and Collaborators
Harvard University
Yale University
Investigators
Principal Investigator: Nicholas A Christakis, MD, PhD Yale University
Study Director: Thomas Keegan, PhD Yale University
  More Information

No publications provided

Responsible Party: Thomas Keegan, Ph.D., Project Director, Yale University
ClinicalTrials.gov Identifier: NCT01672580     History of Changes
Other Study ID Numbers: Lempira_Phase2
Study First Received: August 20, 2012
Last Updated: January 24, 2014
Health Authority: Honduras: Ministry of Health

Keywords provided by Harvard University:
social networks
nutrition
vitamins
chlorine

Additional relevant MeSH terms:
Dysentery
Malnutrition
Nutrition Disorders
Gastroenteritis
Gastrointestinal Diseases
Digestive System Diseases
Intestinal Diseases
Vitamins
Micronutrients
Growth Substances
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on August 21, 2014