Impact of Laparoscopic Gastric Bypass Surgery and Weight Reduction on Lower Esophageal Sphincter (LES)
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Purpose
The purpose with this study is to investigate whether gastric bypass surgery and the following weight reduction impact the tone in esophageal sphincters and the esophageal function.
In a previous study our group used high resolution solid-state manometry to investigate the pressure in the esophagus and esophageal sphincters in obese patients going through laparoscopic bariatric surgery. These studies showed that the barrier pressure between the stomach and esophagus is significantly lower in obese compared to lean patients. In this study the investigators will examine these patients once more, now after weight reduction to see whether the barrier pressure is back to normal compared to lean patients.
| Condition | Intervention |
|---|---|
|
Obesity |
Procedure: Laparoscopic gastric bypass surgery |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Prospective |
| Official Title: | Impact of Laparoscopic Gastric Bypass Surgery and Weight Reduction an Lower Esophageal Sphincter. A Study of Morbidly Obese Patients Before and After Surgery. |
- Variation in lower esophageal sphincter tone due to bariatric surgery and weight reduction [ Time Frame: 12-18 months after surgery ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 30 |
| Study Start Date: | November 2012 |
| Estimated Study Completion Date: | May 2013 |
| Estimated Primary Completion Date: | May 2013 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
| Obese, BMI > 35 | Procedure: Laparoscopic gastric bypass surgery |
Detailed Description:
The prevalence of obesity has increased dramatically in recent decades. The gastrointestinal changes associated with obesity have clinical significance for the anesthesiologist in the perioperative period. The upper and lower esophageal sphincters (UES and LES) play a central role in preventing regurgitation and aspiration. The barrier pressure, defined as the difference between the LES pressure and the Intragastric pressure is known to be lower in obese patients compared to lean patients. This might result in a higher risk of regurgitation and aspiration of stomach contents in during induction of anesthesia.
Some studies are made on patients before and after bariatric surgery but results are sparse. In this study the investigators will examine 30 patients before and after bariatric surgery. Our group have performed the measurements on patients before surgery and presented the results in another article. Those patients will be asked to take part of another measurement now 12-18 months after surgery.
30 patients will be consecutively asked and enrolled in this study. Measurements will be performed using high-resolution-solid state manometry.
Eligibility| Ages Eligible for Study: | 18 Years to 60 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
The initial measurements were made on a group of male and female patients 18-60 years with BMI > 35, ASA-classification 1-3 planned for laparoscopic bariatric surgery.
Inclusion Criteria:
- 18-60 year,
- BMI prior to surgery > 35,
- ASA-classification 1-3
Exclusion Criteria:
- Patient refusal
Contacts and Locations| Sweden | |
| Department of Anesthesiology and Intensive care, University Hospital of Örebro | Not yet recruiting |
| Örebro, Sweden, 70162 | |
| Contact: Alex de Leon, PhD, Specialist +46 19 6021000 | |
| Principal Investigator: Alex de Leon | |
More Information
No publications provided
| Responsible Party: | Alex de Leon, PhD, Specialist in Anaesthesia and Intensive Care, Örebro University, Sweden |
| ClinicalTrials.gov Identifier: | NCT01672034 History of Changes |
| Other Study ID Numbers: | 2011/477 |
| Study First Received: | August 21, 2012 |
| Last Updated: | August 23, 2012 |
| Health Authority: | Sweden: Regional Ethical Review Board |
Additional relevant MeSH terms:
|
Obesity Weight Loss Overnutrition Nutrition Disorders |
Overweight Body Weight Signs and Symptoms Body Weight Changes |
ClinicalTrials.gov processed this record on June 18, 2013