Fludrocortisone and Information Processing in Healthy Volunteers
Stimulating the mineralocorticoid receptor (MR) may restore a disturbed balance as seen in depression. In this double-blind, randomized, placebo-controlled trial the investigators will test the effects of a single dose (500mg) fludrocortisone, an MR-agonist, on the information processing in healthy female volunteers (N = 2x20).
The investigators want to investigate whether the acute administration of fludrocortisone (FC) in healthy females enhances the appraisal of emotional information related to depression, hypothesizing that:
- FC relative to placebo selectively improves the recognition of happy and fearful faces: resulting in more correct responses and faster RTs.
- FC induces a bias towards more positive self-description and an improved memory for positive information.
Female participants were selected because the haplotype MRI180V is related to depression vulnerability in women, not in men. If the effects of fludrocortisone are comparable to the effects of antidepressants on the same tests and the same population, it might be a first indication that fludrocortisone may function as an antidepressant.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:||The Effects of Fludrocortisone on Information Processing in Healthy Female Volunteers|
- Accuracy to recognize emotions in facial expressions [ Time Frame: 2 hrs after intake fludrocortisone or placebo ] [ Designated as safety issue: No ]This primary outcome is measured by performing the Facial Expression Recognition Task (FERT).
- Explicit memory for positive and negative information [ Time Frame: 2 hrs after intake of fludrocortisone or placebo ] [ Designated as safety issue: No ]This primary outcome is measured by the Emotional categorization and Memory(EMT)task. This task consists of two parts, the encoding and recall.
- Subjective mood states [ Time Frame: 2 hrs after intake fludrocortisone or placebo ] [ Designated as safety issue: No ]This is measured by administration of the 'Positive Affect Negative Affect Schedule'(PANAS). It measures positive and negative mood states (tension, vigor, anxiety, fatigue, boredom, alertness...) (20 items adding to two subscales, positive and negative affect).
|Study Start Date:||May 2012|
|Estimated Study Completion Date:||August 2012|
|Estimated Primary Completion Date:||August 2012 (Final data collection date for primary outcome measure)|
Fludrocortisone 500 mg in capsule
single dose 500 mg, capsule
Other Name: Florinef
Placebo Comparator: Placebo
Placebo capsule, single dose, main ingredient lactose
Other Name: Placebo comparator
We found in depressed individuals, compared with non-depressed controls, that MRs had a decreased (approximately -30%) expression in hippocampus, inferior frontal gyrus and cingulate gyrus. It is proposed that decreased expression of MRs is part of the underlying pathological process in depression.
Recent studies have revealed considerable interpersonal differences with regard to the functioning of the MRs. Firstly, common MR gene polymorphisms influence the cortisol awakening response (CAR). Secondly, clinical populations differ in observed depressive symptoms as a function of MRI180V genotype. This MR I180V gene variant showed less activity in vitro, which suggests that functionality in vivo is decreased. Finally, MR haplotype 2, which is prevalent in 35% of the Caucasian population, enhances the transcription, translation and transactivation of the MR. This haplotype is associated with higher dispositional optimism, fewer thoughts of hopelessness and lower risk of major depression. These effects are restricted to pre-menopausal women. This suggests that female sex steroids may interact with the MR gene, thereby modulating resilience. Indeed, it has been shown that progesterone and oestrogen modulate MR-expression in rats. Taken together, mineralocorticoid receptors in the brain are considered to be a new target for the treatment of stress related disorders like depression.
Fludrocortisone (9α fluoro-hydrocortisone) (FC) is a specific MR-agonist currently used to treat diseases of the adrenal cortex, septic shock (Russel, 2008) and occasionally orthostatic hypotension. It is shown that FC significantly inhibits nocturnal HPA axis activity without first depleting MR receptors with an MR-antagonist. This suggests FC have interesting implications in disorders of HPA axis excess, such as depression. Consistent with the idea that the stimulation of the MR might be useful in the treatment of depression, fludrocortisone accelerated the antidepressant effects of the SSRI escitalopram, at least in those patients who responded to escitalopram. This is in line with a previous observation that spironolactone, a MR antagonist, decreased the efficacy of the antidepressant amitriptyline in depressed patients. These studies show that stimulation of the MR might be a useful addition to the treatment of depression. Though, the explanatory mechanism behind these observations remains unclear.
This project is a first step in investigating the potential antidepressant effects of MR stimulation by fludrocortisone. We will test the effects of FC on indices of emotional information processing in healthy volunteers, which is a recently validated model of antidepressant drug action. It has been demonstrated repeatedly that a single dose of an antidepressant changes the processing of emotionally relevant information in healthy volunteers, within a few hours after administration. For instance, one dose of citalopram improved the recognition of facial expressions of fear and happiness relative to placebo in healthy female volunteers. This finding has been replicated with different antidepressants and different populations.
|Contact: Willem van der Does, PhD||+31715278482||VANDERDOES@fsw.leidenuniv.nl|
|Leiden University - Institute of Psychology||Recruiting|
|Leiden, Zuid-Holland, Netherlands, 2333 AK|
|Contact: Willem van der Does, Professor VANDERDOES@fsw.leidenuniv.nl|
|Sub-Investigator: Roel H De Rijk, PhD|
|Sub-Investigator: E R De Kloet, PhD|
|Sub-Investigator: Nic JA Van der Wee, MD PhD|
|Sub-Investigator: Martijn S Van Noorden, MD|
|Sub-Investigator: Erik J Giltay, MD PhD|
|Principal Investigator:||Willem van der Does, Professor||Leiden University Medical Center|