The Tetrad BMI, Leptin, Leptin/Adiponectin (L/A) Ratio and CA-15-3 is a Reliable Biomarker of Breast Cancer (leptin)
Evaluate body mass index (BMI), leptin, Leptin/adiponectin (L/A) ratio and cancer antigen (CA) 15-3 together as reliable biomarkers for breast cancer.
Consecutive patients aged between 40 - 60 years, with breast disease and informed consent.
Patients' Anthropometric and laboratorial characteristics classified by BMI in the group of cancer and patients with benign breast disease as well as biochemical tests of leptin, adiponectin,CA 15-3, hemoglobin, glucose low-density lipoprotein cholesterol (LDLC), high-density lipoprotein cholesterol (HDLC) levels were obtained as well as a blood sample to analyze CA 15-3 levels with a electrochemiluminescence immunoassay.
Using together leptin, L/A ratio, CA 15-3 and BMI could offer a reliable approach to detect high risk women to develop breast cancer.
Female Breast Carcinoma
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Phase 1. Collect Samples of Breast Biopsy Patients Treated at the Hospital Radiology Service Maternal Perinatal Monica Pretelini|
|Study Start Date:||January 2011|
|Study Completion Date:||July 2012|
|Primary Completion Date:||October 2011 (Final data collection date for primary outcome measure)|
breast cancer patients (cases)
Serum levels of leptin, adiponectin and CA 15-3, as well as anthropometric and biochemical parameters were analyzed in 88 female patients attending mammography study. Predictive values of BMI, leptin, L/A ratio and CA 15-3 were determined with 95% confidence interval (CI).
|Principal Investigator:||Jonnathan Guadalupe Santillán Benítez, MSc||Autonomus University Of the State Of México|
|Study Director:||Leobardo Manuel Gómez Oliván, PhD||Universidad Autonoma del Estado de Mexico|
|Study Chair:||Hugo Mendieta Zeron, PhD||Autonomous University of the State of Mexico|