Cancer Biology of Retinoblastoma
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Purpose
Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and sometimes the entire eye. The purpose of this study is to collect the extra tissue from patients who undergo tumor removal for laboratory experiments that will help us understand not only what occurs in retinoblastoma cells but also how cells normally function. Some of these studies will include an evaluation of how cells control the way that genes are expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how cells lose their identity as retinal cells, what changes make retinoblastoma cells different from normal retinal cells, and what changes make some retinoblastomas worse than others.
| Condition |
|---|
|
Retinoblastoma |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Retrospective |
| Official Title: | Cancer Biology of Retinoblastoma |
- Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations [ Time Frame: After appropriate time, e.g., 7, 10, 14 days after reprogramming ] [ Designated as safety issue: No ]Comparison of number of reprogramming events (defined by colony formation assay and normalized for number of cell plated) as well as the time to reprogramming.
Biospecimen Retention: Samples With DNA
retinoblastoma tumor tissue sample
| Estimated Enrollment: | 20 |
| Study Start Date: | July 2012 |
| Estimated Study Completion Date: | December 2017 |
| Estimated Primary Completion Date: | December 2015 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
| retinablastoma tumor tissue |
Eligibility| Ages Eligible for Study: | up to 5 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Retinoblastoma patients undergoing surgical removal of part or all of their tumor, with or without the remainder of the eye
Inclusion Criteria:
- Patient must have retinoblastoma
- Patient must be receiving biopsy, partial surgical excision of the tumor, complete excision of the tumor, or enucleation of the eye as part of their standard care.
- Parental consent
Exclusion Criteria:
- Diagnosis other than Retinoblastoma
- No surgical sampling of tumor is planned as part of standard care
- Parental preference to not participate.
Contacts and Locations| United States, California | |
| Stanford University Cancer Institute | Recruiting |
| Stanford, California, United States, 94305 | |
| Contact: Phillip Garfin 650-497-8953 pgarfin@stanford.edu | |
| Sub-Investigator: Phillip Garfin | |
| Sub-Investigator: Douglas Fredrick | |
| Sub-Investigator: Michael Kareta | |
| Principal Investigator: Sandra Luna-Fineman | |
| Principal Investigator: Julien Sage | |
| Guatemala | |
| Unidad Nacional de Oncologia Pediatrica | Recruiting |
| Guatemala, Guatemala | |
| Contact: Claudia Garrido 50224454204 | |
| Principal Investigator: | Phillip Garfin | Stanford University |
More Information
No publications provided
| Responsible Party: | Stanford University |
| ClinicalTrials.gov Identifier: | NCT01642823 History of Changes |
| Other Study ID Numbers: | PEDSEYE0002 |
| Study First Received: | July 11, 2012 |
| Last Updated: | February 27, 2013 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Stanford University:
|
retinoblastoma |
Additional relevant MeSH terms:
|
Eye Neoplasms Retinoblastoma Neoplasms, Neuroepithelial Neuroectodermal Tumors Neoplasms, Germ Cell and Embryonal Neoplasms by Histologic Type Neoplasms |
Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue Retinal Neoplasms Neoplasms by Site Eye Diseases Retinal Diseases |
ClinicalTrials.gov processed this record on May 16, 2013