Studying Genes Associated With Non-Hodgkin Lymphoma in Young Patients
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research studies genes associated with non-Hodgkin lymphoma in young patients.
Genetic: gene expression analysis
Genetic: polymorphism analysis
Genetic: reverse transcriptase-polymerase chain reaction
Other: laboratory biomarker analysis
|Official Title:||Candidate Gene Variants and Childhood/Adolescent Non-Hodgkin Lymphoma: A Preliminary Investigation|
- Gene variants associated with childhood/adolescent NHL (lymphoblastic and Burkitt lymphomas)
|Study Start Date:||June 2012|
|Estimated Primary Completion Date:||August 2012 (Final data collection date for primary outcome measure)|
- To conduct a preliminary investigation of the effects of loci strongly and consistently associated in prior genome-wide association studies (GWAS) and validation studies of childhood/adolescent acute lymphoblastic leukemia (ALL), adult non-Hodgkin lymphoma (NHL), autoimmune diseases, and atopic diseases on the risk of NHL (lymphoblastic and Burkitt lymphomas) in children and adolescents.
OUTLINE: DNA samples are analyzed by single nucleotide polymorphism and genotyped by fluorogenic polymerase chain reaction (PCR)-based allelic discrimination (Taqman) assays using the ABI Prism 7900HT reverse transcriptase (RT)-PCR system.
|Principal Investigator:||Amy Linabery, PhD||Masonic Cancer Center, University of Minnesota|