Influence of Sodium Bicarbonate on Time-to-exhaustion at Critical Power in Endurance Athletes
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Purpose
During endurance exercise in the heavy and severe intensity domains, the rate at which metabolites that have been associated with the fatigue process (e.g. Pi, ADP, H, and extracellular K) accumulate increases. possibly leading to exercise cessation. Sodium bicarbonate, as a nutritional supplement, has gained attention over the past decades, because it might delay of offset fatigue. To date, there is a controversial discussion about which delivery mode (amount and frequency) might be best in optimizing endurance performance. Since the high ion load consequent to multiple ingestions might increase plasma volume, and consequently decrease bicarbonate concentrations, single acute ingestion could be more beneficial. However, in multi-day competitions or tournaments it might be necessary to use the supplement on a daily basis. Here, the investigators aim at investigating the effects of single dose or multiple dose (on five consecutive days) administration of bicarbonate vs. placebo increases endurance performance and acid-base homeostasis in trained male endurance athletes.
| Condition | Intervention |
|---|---|
|
Performance |
Dietary Supplement: Sodium bicarbonate Dietary Supplement: Placebo |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Crossover Assignment Masking: Double Blind (Subject, Outcomes Assessor) |
- Time-to-exhaustion [ Time Frame: 5 weeks ] [ Designated as safety issue: No ]
| Enrollment: | 12 |
| Study Start Date: | October 2011 |
| Study Completion Date: | January 2013 |
| Primary Completion Date: | August 2012 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Active Comparator: Sodium bicarbonate |
Dietary Supplement: Sodium bicarbonate
Ergogenic effect
|
| Placebo Comparator: Placebo |
Dietary Supplement: Placebo
Placebo effect
|
Eligibility| Ages Eligible for Study: | 18 Years to 45 Years |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | No |
Inclusion criteria: - male
- no cold or temperature at beginning or during the study
- between 18 and 45 years of age
- active in endurance sports (3 to 5 times per week a moderate to hart training)
- non-smoker
- no known cardiovascular or orthopedic problems
- no known limitations of kidney function
- no bearer of a cardiac pacemaker
- no medications with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
- requirements of the health questionnaire fulfilled
Exclusion criteria: - female
- male and age under 18 or over 45 years
- cold or temperature at the beginning or during the study
- untrained (less than 3 moderate trainings per week)
- smoker
- cardiovascular or orthopedic problems
- limitations of the kidney function
- bearer of a cardiac pacemaker
- medication with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
- requirements of the health questionnaire not fulfilled
Contacts and Locations| Switzerland | |
| University Hospital Zurich, Division of Neurology | |
| Zurich, ZH, Switzerland, 8091 | |
| Study Director: | Neurologie: Neurologische Forschung | University Hospital Zurich, Division of Neurology |
| Principal Investigator: | Marco Toigo, PhD | Swiss Federal Institute of Technology Zurich |
More Information
No publications provided
| Responsible Party: | University of Zurich |
| ClinicalTrials.gov Identifier: | NCT01621074 History of Changes |
| Other Study ID Numbers: | nbc |
| Study First Received: | June 12, 2012 |
| Last Updated: | April 11, 2013 |
| Health Authority: | Switzerland: Ethikkommission |
ClinicalTrials.gov processed this record on May 23, 2013