Lean Muscle Function (LEAN)
This pilot study is designed to determine the relationship between intra-myocellular lipids and muscle contractility in fibers from obese and non-obese older adults. Obese participants are being recruited for an on-going weight loss intervention study and this application seeks approval to recruit and enroll a lean comparison group of non-obese older adults. The primary goal of this study is to characterize the contractile properties of single muscle fibers and whole muscle in healthy, non-obese individuals under the same recording conditions the investigators used for the obese population to begin to determine whether fat infiltration accounts for diminished force.
Single Muscle Fibers
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Obesity and Muscle Function Pilot Study|
- Muscle Fiber [ Time Frame: Baseline ] [ Designated as safety issue: No ]
To measure single muscle fiber contractile properties, including specific force, unloaded shortening velocity, and maximum power. We will also measure whole muscle strength and size and fiber fat infiltration. These results will establish a reference database against which data recorded in older obese individuals can be compared.
Primary hypothesis: Single muscle fibers will exhibit more force and power in healthy non-obese than obese older adults due to greater intra-myocellular fat infiltration.
- Muscle Strength [ Time Frame: Baseline ] [ Designated as safety issue: No ]Non-obese older adults will exhibit greater whole muscle strength (absolute and relative to muscle mass and volume) and power than obese, older adults.
Biospecimen Retention: Samples Without DNA
serum and plasma to be retained
|Study Start Date:||June 2012|
|Estimated Study Completion Date:||July 2013|
|Estimated Primary Completion Date:||July 2013 (Final data collection date for primary outcome measure)|
Comparison data from this lean cohort will be compared to the obese older adults are already being collected in an R01-funded study (Improving Muscle for Functional Independence Trial; IRB00009098; NCT01049698)
|Contact: Ashley Widener, BAfirstname.lastname@example.org|
|United States, North Carolina|
|Wake Forest University Health Sciences||Recruiting|
|Winston Salem, North Carolina, United States, 27157|
|Contact: Ashley Widener, BA 336-713-8014 email@example.com|
|Principal Investigator: Barbara Nicklas, PhD|
|Principal Investigator:||Barbara Nicklas, PhD||Wake Forest University|