Prospective Randomized Study of Glucocorticoids in the Impact of the Liver Function and the Prognosis After Hepatectomy of HCC
This study has suspended participant recruitment.
Sponsor:
Eastern Hepatobiliary Surgery Hospital
Information provided by (Responsible Party):
jian zhai, Eastern Hepatobiliary Surgery Hospital
ClinicalTrials.gov Identifier:
NCT01608945
First received: May 29, 2012
Last updated: May 30, 2012
Last verified: May 2012
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Purpose
The major drawback of hepatic pedicle clamping is ischaemia-reperfusion injury with impairment of liver function. Perioperative steroid administration has been advocated to reduce liver damage. The aim of this prospective, randomized study was to determine whether steroid administration can reduce liver injury and impact the prognosis
| Condition | Intervention |
|---|---|
|
Some Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver |
Drug: Hydrocortisone sodium succinate |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
Resource links provided by NLM:
Drug Information available for:
Hydrocortisone acetate
Hydrocortisone
Succinic acid
Hydrocortisone sodium succinate
Hydrocortisone cypionate
Hydrocortisone butyrate
Sodium succinate
Hydrocortisone valerate
Hydrocortisone probutate
U.S. FDA Resources
Further study details as provided by Eastern Hepatobiliary Surgery Hospital:
Primary Outcome Measures:
- liver function [ Time Frame: six months ] [ Designated as safety issue: No ]
| Enrollment: | 60 |
| Study Start Date: | April 2008 |
| Groups/Cohorts | Assigned Interventions |
|---|---|
| steroid,liver function I/R |
Drug: Hydrocortisone sodium succinate
100mg/day
|
Eligibility| Ages Eligible for Study: | 18 Years to 70 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
Study Population
60
Criteria
Inclusion Criteria:
- 18-70 years old
- diametre of the mass>3cm.
- hcc
Contacts and Locations
No Contacts or Locations Provided
More Information
No publications provided
| Responsible Party: | jian zhai, hepatic department, Eastern Hepatobiliary Surgery Hospital |
| ClinicalTrials.gov Identifier: | NCT01608945 History of Changes |
| Other Study ID Numbers: | EHBH112 |
| Study First Received: | May 29, 2012 |
| Last Updated: | May 30, 2012 |
| Health Authority: | China: Ethics Committee |
Keywords provided by Eastern Hepatobiliary Surgery Hospital:
|
steroid liver function prognosis |
Additional relevant MeSH terms:
|
Cortisol succinate Hydrocortisone acetate Hydrocortisone 17-butyrate 21-propionate Hydrocortisone Hydrocortisone-17-butyrate |
Anti-Inflammatory Agents Therapeutic Uses Pharmacologic Actions Dermatologic Agents |
ClinicalTrials.gov processed this record on June 18, 2013