Neuroimaging and Biomarkers in Chronic Visceral Pain

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2014 by University of California, Los Angeles
Sponsor:
Collaborators:
Information provided by (Responsible Party):
Kirsten Tillisch, MD, University of California, Los Angeles
ClinicalTrials.gov Identifier:
NCT01602575
First received: May 17, 2012
Last updated: May 20, 2014
Last verified: May 2014
  Purpose

The purpose of this study is to use functional magnetic resonance imaging (fMRI) to evaluate brain resting state networks, responses to abdominal stimuli and the effect of MBSR Training on these measures. The goal of this study is to identify biomarkers of IBS and assess the responsiveness these biomarkers after MBSR Training. A biomarker, or biological marker, is in general a substance or measure used as an indicator of a biological state. It is a characteristic that is measured and evaluated as an indicator of normal biological processes, disease processes, or responses to a therapeutic intervention, in this case MBSR.


Condition Intervention
Irritable Bowel Syndrome
Behavioral: Mindfulness based Stress Reduction Training (MBSR)

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Neuroimaging Biomarkers of Mind-Body Treatment Response in Chronic Visceral Pain

Further study details as provided by University of California, Los Angeles:

Primary Outcome Measures:
  • Validate Optimal Biomarker candidates [ Time Frame: After MBSR training (8 weeks). ] [ Designated as safety issue: No ]
    To validate optimal brain biomarker candidates by assessment of treatment responsiveness in IBS patients following and 8 week course in Mindfulness Based Stress Reduction (MBSR).


Secondary Outcome Measures:
  • Specificity, generality and moderation of biomarker response to MBSR treatment. [ Time Frame: Post MBSR training at 3 month follow up. ] [ Designated as safety issue: No ]

    Specificity of biomarker response to MBSR measured by changes in selected biomarker candidates correlation w/improvement in mindfulness at end of treatment & 3-month f/u.

    Determine generality of optimal biomarkers via examination of factors such as sex, age, co-morbid pain,mood, and/or baseline disease severity, as moderators of biomarker performance.

    Moderation of biomarker performance by symptoms: Disease severity, duration, and comorbid symptoms.



Estimated Enrollment: 90
Study Start Date: January 2013
Estimated Study Completion Date: May 2016
Estimated Primary Completion Date: January 2016 (Final data collection date for primary outcome measure)
Intervention Details:
    Behavioral: Mindfulness based Stress Reduction Training (MBSR)
    8 (2 hr) classes weekly of MBSR and required homework of MBSR practice approximately 30 minutes per day.
    Other Names:
    • Spastic colon
    • Irritable colon
    • MBSR
    • Mindfulness Meditation
Detailed Description:

Irritable bowel syndrome (IBS) is the most common chronic visceral pain disorder ranking among the most common of all persistent pain disorders with prevalence rates of 8-12% of the population.3 Diagnostic criteria for IBS include persistent abdominal pain and/or discomfort associated with changes in bowel habit. In the majority of patients, symptoms of other co-morbid pain conditions, such as epigastric pain (functional dyspepsia), pelvic pain (IC/PBS) and musculoskeletal pain (FM) are reported. Estimates are that >50% of the U.S. workforce experiences some type of pain and 13% lose productive work time due to pain over a 2 week period, leading to over 60 billion dollars per year in lost productivity costs.4 There are no generally agreed upon biomarkers for IBS, and diagnoses are exclusively based on subjective symptom criteria. As with most of the persistent pain disorders, IBS patients and their providers have increasingly embraced a biopsychosocial model incorporating psychological and social factors along with physiologic factors, and this forms the basis for integrative treatment approaches. This multimodal approach often incorporates Mind-Body treatments, and there is a growing literature showing clinical efficacy in IBS for interventions incorporating such Mind-Body approaches as meditation, hypnosis, yoga and cognitive therapy.5 However, there is little understanding of the physiological mechanisms underlying mind-body therapies, and for this reason optimization of the treatments for specific individuals and populations is difficult.

In this project we aim to use neuroimaging based biomarkers of IBS to examine which of these physiological measures show changes specific to a mind-body treatment with previously documented efficacy, Mindfulness Based Stress Reduction Training or MBSR. MBSR was chosen as a target treatment for several reasons: Recent clinical trial data suggests there is efficacy in improving IBS symptoms with MBSR, it has demonstrated prior success with other chronic pain conditions and there is considerable literature on meditation associated brain changes.

The primary Objective is to validate optimal biomarker candidates by assessment of treatment responsiveness in IBS patients following Mindfulness Based Stress Reduction (MBSR). The secondary objectives are to determine the generality of optimal biomarkers from Aim 1 and 2 and look at factors such as sex, age, co-morbid pain or mood symptoms, and/or baseline disease severity as moderators of the performance of candidate biomarkers.

Also, exploratory analyses will be performed to assess the effect of an 8 week MBSR training on measures of disease cognition, quality of life and mood defined by pre and post test scores on the behavioral measures listed in the study methods.

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Patients must meet the Rome III criteria for IBS and lack red flag symptoms, such as weight loss, bloody stool, and fever. In the setting of clinical uncertainty on the part of the examining gastroenterologist, laboratory testing or prior medical records may be requested.
  2. Upper gastrointestinal symptoms, ie. dyspepsia or heartburn, are acceptable as long as IBS is their most bothersome symptom complex.
  3. Subject cannot have completed structured training in MBSR or other mindfulness or meditation.
  4. Subject cannot be currently practicing MBSR.
  5. A minimal severity score of 75 on the IBS-SSS at screening will be required to ensure at least mild-moderate symptoms at baseline.
  6. Literate in English
  7. Ambulatory without a need for assistive devices.
  8. Able to participate in the sitting and mild yoga positions required for the MBSR course.
  9. Right handed due to importance of laterality in brain imaging analysis
  10. Not pregnant, nursing or postpartum.
  11. No metals in body, including ferrous metallic implants and tattoos
  12. No history of claustrophobia.
  13. Able to lay still on back for extended period of time ( about 90 minutes).
  14. if unable to participate in the MRI portion of the study you may be eligible to come to the MBSR classes at no cost if you agree to complete the classes, homework and on-line questionnaires.

Exclusion criteria:

  1. Planned major medical intervention in the next 6 months (e.g. surgery), or surgery in the past 6 months.
  2. Presence of a significant and ongoing medical problem that would interfere with participation in the study or testing the study hypotheses (e.g. major heart disease, neurological disorders, inflammatory bowel disease, etc).
  3. Presence of a major psychiatric diagnosis such as schizophrenia, Bipolar disorder, Post-traumatic Stress Disorder, or Obsessive Compulsive disorder. However, subjects with a history of DSMIV diagnosis of Anxiety or Depression, in whom symptoms are not active will be allowed but noted for post-hoc analysis.
  4. use of centrally acting medications that will interfere with the neuroimaging testing (e.g. narcotic medications). As in past studies we will allow subjects taking stable doses of antidepressant medications (TCAs, SSRIs, SNRIs) for at least six months prior to study to participate.
  5. Body Mass Index greater than 30.
  6. Current or past history of chronic pain syndrome other than IBS in the IBS group (pain >6 months at any location).
  7. History of gastrointestinal surgery other than uncomplicated appendectomy or cholecystectomy.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01602575

Contacts
Contact: Jean E Stains, RN/BSN 310-206-1758 jstains@mednet.ucla.edu
Contact: Suzanne R Smith, RN/FNP 310-206-0310 srsmith@mednet.ucla.edu

Locations
United States, California
Oppenheimer Center for Neurobiology of Stress Recruiting
Los Angeles, California, United States, 90095
Contact: Jean Stains, RN    310-206-1758    jstains@mednet.ucla.edu   
Principal Investigator: Kirsten Tillisch, MD         
Sponsors and Collaborators
University of California, Los Angeles
Investigators
Principal Investigator: Kirsten Tillisch, MD University of California, Los Angeles
  More Information

No publications provided

Responsible Party: Kirsten Tillisch, MD, Principal Investigator, University of California, Los Angeles
ClinicalTrials.gov Identifier: NCT01602575     History of Changes
Other Study ID Numbers: RO1AT007137, NIH/NCCAM
Study First Received: May 17, 2012
Last Updated: May 20, 2014
Health Authority: United States: Data and Safety Monitoring Board
United States: Institutional Review Board

Keywords provided by University of California, Los Angeles:
IBS, FMRI, MBSR

Additional relevant MeSH terms:
Visceral Pain
Nociceptive Pain
Pain
Irritable Bowel Syndrome
Colonic Diseases, Functional
Colonic Diseases
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on August 20, 2014