The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers (Nanoexposure)
Investigation of the differences between the levels of extracellular and intracellular nano-particles in workers exposed to environmental particles during their employment to enhance understanding the process of penetration of the particles to respiratory epithelial cells.
Inadequate or Impaired Respiratory Function
|Study Design:||Observational Model: Case-Only
Time Perspective: Cross-Sectional
|Official Title:||The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers (Nanoexposure)|
- Analysis of the size distribution of nano-particles in exhaled breath condensate [ Time Frame: One year ] [ Designated as safety issue: Yes ]Each subject will be examined once. The total time for collection of data is estimated as about one year.
|Study Start Date:||May 2012|
|Estimated Study Completion Date:||May 2013|
|Estimated Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
This study investigates the following questions:
Does occupational exposure to nanoparticles influence permeation of such particles to respiratory airways? Is there a correlation between the levels of nanoparticles in sample biological fluids of the patients and their pulmonary functions.
Is there a correlation between the levels of nanoparticles in sample biological fluids of the patients and respiratory tract infections.
The study protocol includes the following steps:
Initial interview of the patient Measurement of nanoparticles in samples of exhaled breath condensate using NanoSight LM 20 Measurement of nanoparticles in induced sputum. And finally examination of the relationship between the measured parameters and the indices of pulmonary infection, and pulmonary function as measured by the pulmonary department of the TASMC.
|Contact: Yehuda Schwarz, M.D.||email@example.com|
|Principal Investigator:||Yehuda Schwarz, M.D.||Tel Aviv Sourasky Medical Center (TASMC, Ichilov)|