Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients
Recruitment status was Active, not recruiting
Patients who are dependent on opioids often have poor pain relief after major surgery. This study tests the hypothesis that adding intravenous ketamine to a postoperative regimen of intravenous opioids for postoperative pain will improve pain relief in this subset of patients.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:||Hydromorphone PCA or Hydromorphone PCA With Ketamine for Acute Postoperative Pain Relief in Opioid-Dependent Chronic Pain Patients|
- Pain relief [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of 3 days ] [ Designated as safety issue: No ]Evaluate efficacy of ketamine for postop pain control in opioid-dependent patients who receive ketamine in addition to postop patient controlled analgesia with opioids
|Study Start Date:||September 2008|
|Estimated Study Completion Date:||June 2012|
|Primary Completion Date:||June 2011 (Final data collection date for primary outcome measure)|
Active Comparator: Ketamine
Ketamine is being compared to the use of placebo, in addition to intravenous opioids, for postop pain control in opioid dependent patients who undergo major surgery.
IV ketamine 0.2 mg/kg/hr for 24-48 hours postoperatively.
Placebo Comparator: Placebo
Patients who received placebo recieved an infusion of saline.
Patients who received placebo were given saline infusions
Please refer to this study by its ClinicalTrials.gov identifier: NCT01591382
|United States, Massachusetts|
|Brigham and Women's Hospital|
|Boston, Massachusetts, United States, 02115|
|Principal Investigator:||Srdjan S Nedeljkovic, M.D.||Brigham and Women's Hospital|