Hereditary Haemorrhagic Telangiectasia Flight Safety Study (Flying and HHT)
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Purpose
Hereditary Haemorrhagic Telangiectasia (HHT) is a condition in which sufferers have abnormal blood vessels which makes them more likely to bleed than other people, particularly in the lungs, which results in low blood oxygen levels. Flying may make this worse and cause problems. The investigators want to know if there are an increased number of problems on flights compared to on land.
The investigators currently do not have any evidence based guidelines on air travel to best advice people who suffer with HHT. The investigators would therefore like to ask individuals who have HHT about their experience on a flight, using a postal questionnaire.
| Condition | Intervention |
|---|---|
|
Hereditary Haemorrhagic Telangiectasia |
Other: Aeroplane flight in the past- no active intervention for study Other: Questionnaire |
| Study Type: | Observational |
| Study Design: | Time Perspective: Retrospective |
| Official Title: | A Questionnaire Based Study to Evaluate the Safety of Flying in Hereditary Haemorrhagic Telangiectasia (HHT) |
- Self reported medical complication [ Time Frame: During or in 6 weeks post flight ] [ Designated as safety issue: No ]
| Enrollment: | 145 |
| Study Start Date: | January 2010 |
| Study Completion Date: | October 2011 |
| Primary Completion Date: | October 2011 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
| Pateints with hereditary haemorrhagic telangiectasia |
Other: Aeroplane flight in the past- no active intervention for study
Aeroplane flight(s) previously taken by study participants
Other: Questionnaire
Flight by aeroplane (previous)
|
Detailed Description:
Individuals with Hereditary Haemorrhagic Telangiectasia (HHT) previously reviewed at HHTIC London will be sent an invitation to participate in a short questionnaire study.
Quantitative variables from the questionnaires for statistical analysis will be the number of individuals responding (and number of questionnaires sent out); number of flights taken and number of complications, subgrouped by type, and flight duration in hours. Complication rates will be expressed as proportion of person flight hours.
The quantitative data from the questionnaire will then be compared with quantitative data from patients' medical records using non parametric methods such as Mann Whitney for univariate analyses.
Eligibility| Ages Eligible for Study: | 16 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
HHT patients previously assesses at Hammersmith Hospital, England
Inclusion Criteria:
HHT
Exclusion Criteria:
Unable to provide informed consent
Contacts and Locations| United Kingdom | |
| HammersmithHospital, Imperial College Healthcare NHS Trust | |
| London, United Kingdom, W12 0NN | |
| Principal Investigator: | Claire L Shovlin, PhD MA MB BChir FRCP | Imperial College London |
More Information
No publications provided
| Responsible Party: | Imperial College London |
| ClinicalTrials.gov Identifier: | NCT01590121 History of Changes |
| Other Study ID Numbers: | CLS/20 |
| Study First Received: | April 30, 2012 |
| Last Updated: | May 1, 2012 |
| Health Authority: | UK: NRES |
Keywords provided by Imperial College London:
|
Previous flight by aeroplane |
Additional relevant MeSH terms:
|
Telangiectasia, Hereditary Hemorrhagic Telangiectasis Hemostatic Disorders Vascular Diseases Cardiovascular Diseases |
Hemorrhagic Disorders Hematologic Diseases Vascular Malformations Cardiovascular Abnormalities Congenital Abnormalities |
ClinicalTrials.gov processed this record on June 17, 2013