Proton Pump Inhibitor Use is Associated With High Risk of Pneumonia in Chronic Kidney Disease Patients
Chronic kidney disease is a severe medical problem in Taiwan public health issue, which the highest incidence and prevalence rate in the world.Proton pump inhibitors may increase the risk of pneumonia appearance, which were caused by profound irreversible gastric acid suppression. The study purpose was to characterize difference of developing pneumonia in chronic kidney disease of prior use proton pump inhibitors.
Chronic Kidney Disease
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||Institute of Emergency and Critical Care Medicine , School of Yang-Ming University|
- Chronic kidney disease ICD-9 [ Time Frame: 2012-Dec ] [ Designated as safety issue: Yes ]
|Study Start Date:||March 2012|
|Estimated Study Completion Date:||November 2013|
|Primary Completion Date:||June 2012 (Final data collection date for primary outcome measure)|
CKD with PPI use, follow up at least 5 years began PPI use
with or without Pneumonia outcome
Patients were eligible for inclusion if they received any PPIs treatment between January 1, 1998 and December 31, 2002 and had been diagnosed with pneumonia between January 1, 1998 and December 31, 2008 in an inpatient setting.
The study used data from Taiwan Health Insurance Research Database; the investigators conducted a population-based cohort study in Taiwan. Case consisted of all patients who had a first diagnosis of chronic kidney disease for the period between 1997 and 2008. The investigators utilized the use of Proton pump inhibitor from chronic kidney disease patients.