Studying Gene Expression and Location in Samples From Patients With Brain Tumors

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2012 by National Cancer Institute (NCI).
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01585389
First received: April 24, 2012
Last updated: April 29, 2012
Last verified: April 2012
  Purpose

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to brain tumors.

PURPOSE: This research studies gene expression and location in samples from patients with brain tumors.


Condition Intervention
Brain and Central Nervous System Tumors
Genetic: gene expression analysis
Genetic: genetic linkage analysis
Genetic: microarray analysis
Other: immunohistochemistry staining method
Other: laboratory biomarker analysis

Study Type: Observational
Official Title: Expression and Subcellular Localization of NEIL3 in Tumors

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Correlation of NEIL3 expression and/or nuclear localization with tumor type or grade with respect to degree of differentiation [ Designated as safety issue: No ]

Estimated Enrollment: 10
Study Start Date: April 2012
Estimated Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
Detailed Description:

OBJECTIVES:

  • To determine the expression and subcellular localization of nei endonuclease VIII-like 3 (NEIL3) in brain tumors.

OUTLINE: Tissue microarray samples are analyzed for NEIL3 expression and subcellular localization by immunohistochemical methods.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Tissue microarrays (TMA) samples from the Biopathology Core
  • Samples from patients diagnosed with brain tumors

    • Progenitor, or blast, cell origin

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01585389

Sponsors and Collaborators
Children's Oncology Group
Investigators
Principal Investigator: Heithem M. El-Hodiri, PhD Nationwide Children's Hospital
  More Information

Additional Information:
No publications provided

Responsible Party: Peter C. Adamson, Children's Oncology Group - Group Chair Office
ClinicalTrials.gov Identifier: NCT01585389     History of Changes
Other Study ID Numbers: CDR0000732178, COG-ABTR12B3
Study First Received: April 24, 2012
Last Updated: April 29, 2012
Health Authority: United States: Federal Government

Keywords provided by National Cancer Institute (NCI):
adult brain tumor
childhood brain tumor

Additional relevant MeSH terms:
Brain Neoplasms
Nervous System Neoplasms
Central Nervous System Neoplasms
Neoplasms by Site
Neoplasms
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases

ClinicalTrials.gov processed this record on July 23, 2014