Serum Cartilage Oligomeric Matrix Protein Accumulation Decreases Significantly After 12 Weeks of Running

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Feza Korkusuz, Middle East Technical University
ClinicalTrials.gov Identifier:
NCT01576159
First received: April 9, 2012
Last updated: April 12, 2012
Last verified: April 2012
  Purpose

Acute effects of physical exercise on the deformational behavior of articular cartilage and changes in cartilage oligomeric matrix protein (COMP) are definite. However, conclusive positive effects of fitness exercise on functional adaptation of articular cartilage have not been proved.Therefore, in this parallel-group randomized control trial, the investigators tested the hypothesis that adequate amount of physical exercise with enough impact would be able to stimulate the functional behavior of articular cartilage.

The investigators evaluated 44 healthy males for their physical fitness levels and their blood samples were obtained before, immediately after and 0.5 h after a 30-min walking exercise. Thereafter, participants were assigned to the running, the cycling, the swimming and the control groups. At the end of 12-weeks of intervention, same measurement procedures were applied. Mixed repeated-measures ANOVA design was used for statistics. (Level of evidence: 2)


Condition Intervention Phase
Osteoarthritis
Articular Cartilage Disorder of Knee
Degenerative Lesion of Articular Cartilage of Knee
Other: Running exercise
Other: Cycling exercise
Other: Swimming Exercise
Phase 0

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Screening
Official Title: The Effect of Mechanical Loading During Sports Exercises on Degradation of Human Articular Cartilage

Resource links provided by NLM:


Further study details as provided by Middle East Technical University:

Primary Outcome Measures:
  • Changes in serum COMP accumulation, triggered by acute exercise, after 12 weeks of different regular exercises [ Time Frame: Baseline and 14 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Physical changes of participants [ Time Frame: Baseline and 14 weeks ] [ Designated as safety issue: No ]
  • Physiological changes of participants [ Time Frame: Baseline and 14 weeks ] [ Designated as safety issue: No ]

Enrollment: 44
Study Start Date: January 2008
Study Completion Date: September 2008
Primary Completion Date: June 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: High-Impact Loading
Performed high-impact running exercise during intervention period.
Other: Running exercise
During this type of exercise intervention, subjects performed weight-bearing exercise. This group participated in sessions of 40-min per day, three days per week, for a period of 12 weeks
Experimental: Moderate-Impact Loading
Performed moderate-impact cycling exercise during intervention period.
Other: Cycling exercise
During this type of exercise intervention, subjects performed a partial weight-bearing exercise. This group participated in sessions of 40-min per day, three days per week, for a period of 12 weeks
Experimental: Non-Impact Loading
Performed low-impact swimming exercise during intervention period.
Other: Swimming Exercise
During this type of exercise intervention, subjects performed a non-weight bearing exercise. This group participated in sessions of 40-min per day, three days per week, for a period of 12 weeks
No Intervention: Control Group
Didn't participate any organized physical exercises

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years to 25 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • body mass index lower than 30
  • availability of participants for the tests and attendance to training sessions

Exclusion Criteria:

  • osteoarthritis, rheumatoid arthritis or other inflammatory joint disease
  • intra-articular steroid injection
  • mal-alignment of the knees (varus/valgus) larger than 15°
  • recent (within six months) fracture of lower extremity.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01576159

Locations
Turkey
Middle East Technical University, Medical Center and Physical Education and Sports Dep.
Ankara, Cankaya, Turkey, 06531
Sponsors and Collaborators
Middle East Technical University
Investigators
Study Director: Ozgur Celik, PhD Middle East Technical University
Principal Investigator: Feza Korkusuz, PhD Middle East Technical University
  More Information

Publications:
Responsible Party: Feza Korkusuz, Prof. Dr., Middle East Technical University
ClinicalTrials.gov Identifier: NCT01576159     History of Changes
Other Study ID Numbers: BAPK06K07K03K00K17, 107S112
Study First Received: April 9, 2012
Last Updated: April 12, 2012
Health Authority: Turkey: Ethics Committee

Keywords provided by Middle East Technical University:
Biochemical Marker
Fitness Exercises
Impact
Articular Cartilage

Additional relevant MeSH terms:
Cartilage Diseases
Osteoarthritis
Musculoskeletal Diseases
Connective Tissue Diseases
Arthritis
Joint Diseases
Rheumatic Diseases

ClinicalTrials.gov processed this record on August 26, 2014