Non Invasive and Non-Contact Dual-modal Imaging Of Tissue Oxygenation and Vascular Reactivity Dynamic Imaging Of Tissue Metabolism and Vascular Function. - Full Text View

Purpose

Quantitative validation of non-contact oxygenation imaging by the CWC imaging system,
Quantitative validation of non-contact vascular function imaging by the CWC imaging system,
Evaluation of the clinical usability of the CWC imaging system for further technology development and engineering improvement.

Condition
Quantitative Validation of Imaging System

Study Type:	Observational
Study Design:	Time Perspective: Prospective
Official Title:	Non Invasive and Non-Contact Dual-modal Imaging Of Tissue Oxygenation and Vascular Reactivity Dynamic Imaging Of Tissue Metabolism and Vascular Function.

Further study details as provided by Ohio State University:

Biospecimen Retention: None Retained

there is no biospecimen collection require in this protocol.

Estimated Enrollment:	50
Study Start Date:	August 2011
Estimated Study Completion Date:	August 2013
Estimated Primary Completion Date:	August 2013 (Final data collection date for primary outcome measure)

Groups/Cohorts
1 Healthy participants.

Detailed Description:

The hyperspectral imaging technique estimates cutaneous tissue oxygenation by illuminating tissue and detect tissue reflectance at different wavelengths non-invasive and non-contact detection of tissue functional properties.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Probability Sample

Study Population

Interested Healthy volunteers.

Criteria

Inclusion Criteria:

Adult 18 years and above
No history of diabetes.
No history of vascular disease

Exclusion Criteria:

Under 18 years of age
Unable to provide informed consent
Prisoners
Current smoker

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01573390

Contacts

Contact: Surya C Gnyawali, Ph.D.

surya.gnyawali@osumc.edu

Locations

United States, Ohio
The Ohio State University.	Recruiting
Columbus, Ohio, United States, 43210
Contact: Surya C Gnyawali, Ph.D. surya.gnyawali@osumc.edu

Sponsors and Collaborators

Chandan K Sen

Investigators

Principal Investigator:

Chandan K Sen, Ph.D.

Ohio State University

More Information

Publications:

Xu RX, Huang K, Qin R, Huang J, Xu JS, Ding L, Gnyawali US, Gordillo GM, Gnyawali SC, Sen CK. Dual-mode imaging of cutaneous tissue oxygenation and vascular function. J Vis Exp. 2010 Dec 8;(46). pii: 2095. doi: 10.3791/2095.

Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999 Sep 2;341(10):738-46. Review. No abstract available.

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Broughton G 2nd, Janis JE, Attinger CE. Wound healing: an overview. Plast Reconstr Surg. 2006 Jun;117(7 Suppl):1e-S-32e-S. Review.

Sen CK. Wound healing essentials: let there be oxygen. Wound Repair Regen. 2009 Jan-Feb;17(1):1-18. Review.

Leach RM, Treacher DF. Oxygen transport-2. Tissue hypoxia. BMJ. 1998 Nov 14;317(7169):1370-3. Review.

Treacher DF, Leach RM. Oxygen transport-1. Basic principles. BMJ. 1998 Nov 7;317(7168):1302-6. Review.

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Shah SA, Bachrach N, Spear SJ, Letbetter DS, Stone RA, Dhir R, Prichard JW, Brown HG, LaFramboise WA. Cutaneous wound analysis using hyperspectral imaging. Biotechniques. 2003 Feb;34(2):408-13.

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Luypaert R, Boujraf S, Sourbron S, Osteaux M. Diffusion and perfusion MRI: basic physics. Eur J Radiol. 2001 Apr;38(1):19-27. Review.

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Greenman RL, Panasyuk S, Wang X, Lyons TE, Dinh T, Longoria L, Giurini JM, Freeman J, Khaodhiar L, Veves A. Early changes in the skin microcirculation and muscle metabolism of the diabetic foot. Lancet. 2005 Nov 12;366(9498):1711-7.

Myers DE, Anderson LD, Seifert RP, Ortner JP, Cooper CE, Beilman GJ, Mowlem JD. Noninvasive method for measuring local hemoglobin oxygen saturation in tissue using wide gap second derivative near-infrared spectroscopy. J Biomed Opt. 2005 May-Jun;10(3):034017.

Khaodhiar L, Dinh T, Schomacker KT, Panasyuk SV, Freeman JE, Lew R, Vo T, Panasyuk AA, Lima C, Giurini JM, Lyons TE, Veves A. The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes. Diabetes Care. 2007 Apr;30(4):903-10. Epub 2007 Feb 15.

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Responsible Party:	Chandan K Sen, Professor, The Ohio State University
ClinicalTrials.gov Identifier:	NCT01573390 History of Changes
Other Study ID Numbers:	2010H0017
Study First Received:	April 5, 2012
Last Updated:	November 28, 2012
Health Authority:	United States: Institutional Review Board

Keywords provided by Ohio State University:

Non-invasive
tissue-oxygenation
hyperspectral
CWC imaging system

ClinicalTrials.gov processed this record on May 22, 2013