Circulating SIRT6 Expression, Effect on Aging Quality (Sirt6)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Hospices Civils de Lyon
ClinicalTrials.gov Identifier:
NCT01567176
First received: March 8, 2012
Last updated: January 17, 2013
Last verified: February 2012
  Purpose

This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging. The investigators seek to confirm this difference in expression level of circulating leukocytes on a larger sample.


Condition Intervention
Aging
Biological: Blood sample

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Circulating Expression Measurement of a Sirtuin Protein Isoform, Sirt6, as an Early Marker of Aging Quality

Further study details as provided by Hospices Civils de Lyon:

Primary Outcome Measures:
  • Sirt6 expression in circulating leukocytes based on the aging quality [ Time Frame: participants will be followed for the duration of the visit, an expected average of 1 day ] [ Designated as safety issue: No ]
    analysis by quantitative RT-PCR method


Secondary Outcome Measures:
  • hand and forearm muscular strength measurement [ Time Frame: participants will be followed for the duration of the visit, an expected average of 1 day ] [ Designated as safety issue: No ]
    Hand Grip strength test

  • Physical examination and anthropometric measurement [ Time Frame: participants will be followed for the duration of the visit, an expected average of 1 day ] [ Designated as safety issue: No ]
    Measurement of the weight, height, waist, hips, blood pressure, pulse.

  • Cognitive assessment [ Time Frame: participants will be followed for the duration of the visit, an expected average of 1 day ] [ Designated as safety issue: No ]
    MMSE (Mini Mental State Examination), Five-word test, clock drawing

  • Physical Activity questionnaire [ Time Frame: participants will be followed for the duration of the visit, an expected average of 1 day ] [ Designated as safety issue: No ]
    MAQ (Modifiable Activity Questionnaire)


Enrollment: 60
Study Start Date: March 2012
Study Completion Date: September 2012
Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Single Arm Biological: Blood sample
It is a single cross sectional study. All outcome measures will be taken during the investigation with physical examination, questionnaire and a blood sample

  Eligibility

Ages Eligible for Study:   60 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Volunteers from the SUVIMAX 2 aging cohort
  • Men and women
  • Older than 60
  • Subject with a global aging quality score of 1 or 3 in the SU.VI.MAX. 2 study
  • Covered by Health Insurance System

Exclusion Criteria:

  • Subject not in compliance with the recommendation of French National Law
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01567176

Locations
France
Centre de recherche en nutrition humaine Rhone-Alpes
Pierre Bénite, France, 69310
Centre de Recherche en Nutrition Humaine
Pierre Bénite, France, 69310
Sponsors and Collaborators
Hospices Civils de Lyon
Investigators
Principal Investigator: Martine LAVILLE, Pr Centre de recherche en nutrition humaine Rhone-Alpes
  More Information

No publications provided

Responsible Party: Hospices Civils de Lyon
ClinicalTrials.gov Identifier: NCT01567176     History of Changes
Other Study ID Numbers: 2011.674
Study First Received: March 8, 2012
Last Updated: January 17, 2013
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Keywords provided by Hospices Civils de Lyon:
Sirtuins
Aging
Metabolic disease

ClinicalTrials.gov processed this record on July 31, 2014