The Influence of Amitriptyline on Learning in a Visual Discrimination Task
The purpose of this study is to determine whether 75 mg amitriptyline affect the sleep dependent consolidation of procedural memory (visual discrimination task, Karni-Sagi-paradigm).
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
|Official Title:||The Influence of Amitriptyline (Amitriptylin-CT 25 mg®) on Learning in a Visual Discrimination Task (Karni-Sagi-paradigm)|
- changes in the visual discrimination task's perception threshold [ Time Frame: The visual discrimination task's perception treshold is assessed before sleep (day 10 at 6 pm) and after sleep (day 11 at 6 pm). ] [ Designated as safety issue: No ]Improvement in this task is defined as a decrease in the perception threshold between training and retrieval testing.
- amount of rapid eye movement (REM) sleep (sleep period time percentage) [ Time Frame: night from day 10 to day 11 ] [ Designated as safety issue: No ]
|Study Start Date:||August 2008|
|Study Completion Date:||May 2009|
|Primary Completion Date:||May 2009 (Final data collection date for primary outcome measure)|
|Active Comparator: Amitriptyline||
amitriptyline 25 mg at 9:30 pm, day 10, and 50 mg at 1:30 am, day 11
Other Name: Saroten
|Placebo Comparator: white 8 mm Lichtenstein®||
placebo(white 8 mm Lichtenstein®) at 9:30 pm, day 10, and at 1:30 am, day 11
Rapid eye movement (REM) sleep is considered critical to the consolidation of procedural memory - the memory of skills and habits. Many antidepressants strongly suppress REM sleep, however, and procedural memory consolidation has been shown to be impaired in depressed patients on antidepressant therapy. As a result, it is important to determine whether antidepressive therapy can lead to amnestic impairment. We thus investigate the effects of the anticholinergic antidepressant amitriptyline on sleep-dependent memory consolidation in 32 healthy men in a double-blind, placebo-controlled, randomized parallel-group study.
|Charité - Universitätsmedizin Berlin, Department of Physiology CBF|
|Berlin, Germany, 10115|
|Study Chair:||Dieter Kunz, MD||Charite University, Berlin, Germany|
|Principal Investigator:||Dieter Kunz, MD||Charite University, Berlin, Germany|