Trial record 1 of 37 for:    "progressive supranuclear palsy"
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Postural Instability in Progressive Supranuclear Palsy

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2012 by Oregon Health and Science University.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
Bernadette Schoneburg, Oregon Health and Science University
ClinicalTrials.gov Identifier:
NCT01563276
First received: March 22, 2012
Last updated: March 23, 2012
Last verified: March 2012
  Purpose

The purpose of this study is to better understand why individuals with Progressive Supranuclear Palsy (PSP) fall. Understanding the mechanism of gait and balance dysfunction in individuals with PSP may provide us with important early diagnostic tools, allowing for earlier identification of mobility problems and to better evaluate medical therapies aimed at improving motor disability.

The investigators will recruit 10 PSP, 10 PD and 10 healthy controls for the study. All subjects will be asked to come to the OHSU clinic at the Center for Health and Healing for an initial screening visit. They will meet with the primary investigator to conduct a brief interview and physical examination. In addition, they will be asked to answer questions regarding current and past medical illness, how often they fall and what kinds of medications they are on.

Subjects who agree to participate will come to the Oregon Clinical and Translational Research Institute (OCTRI) at OHSU for balance testing. Subjects will be asked to stand or sit on a movable platform with eyes open or closed. Prior to standing on the platform, the investigators will place 6 small sensors on body which are held in place by velcro straps (one on each wrist, ankles, chest and lower back). The platform will then be moved (tilt or slide) while subjects try to keep their balance. During all of the balance tests described above, body movements will be recorded from the sensors on the subjects' body. This data is directly recorded by a computer and analyzed to help us gain better understanding of the subjects' posture and their ability to remain up right.


Condition
Progressive Supranuclear Palsy
Parkinson's Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Postural Instability in Progressive Supranuclear Palsy: Why do Patients With PSP Fall?

Resource links provided by NLM:


Further study details as provided by Oregon Health and Science University:

Primary Outcome Measures:
  • Relative contributions of vestibular and visual information to postural control in PSP [ Time Frame: Single visit. 2 hours. ] [ Designated as safety issue: No ]
    To gage the relative contributions of vestibular and visual information to postural control in PSP we will measure body sway using two different tests (LOS and SOT) while a patient stands on a movable force plate within a movable visual surround.


Secondary Outcome Measures:
  • Postural Response Latencies [ Time Frame: Single visit. 2 hours. ] [ Designated as safety issue: No ]
    Subjects will stand on a movable platform with a movable visual surround. Subjects will be asked to keep their balance while the platform is translated or roated.

  • Gait patterns and postural transitions [ Time Frame: Single visit. 10 minutes. ] [ Designated as safety issue: No ]
    Subjects will be asked to rise from a chair, walk and turn. Ambulatory balance will be measured by a time up and go test (TUG). Six accelerometers will be placed on the subject and will measure parameters including arm swing, number of steps and turn duration.

  • Perception of vertical and horizontal references [ Time Frame: Single visit. 2 hours. ] [ Designated as safety issue: No ]
    Subjects will perform two different tasks with their eyes closed while standing and sitting on a force plate that is tilting in the antero-posterior direction. They will perform the following two tasks: 1. Hold a rod parallel to the gravitional vertical 2. Hold a rod perpendicular to the tilting surface so it remains 90 degrees to the surface at all times. Six accelerometers will measure lower and upper body tilt.


Estimated Enrollment: 40
Study Start Date: December 2011
Groups/Cohorts
Progressive Supranuclear Palsy
Patients with a diagnosis of probable or possible PSP as defined by the National Institute of Neurological Disorders and Stroke and Society for Progressive Supranuclear Palsy (NINDS-SPSP) diagnostic criteria.
Parkinson's Disease
Idiopathic PD according to the UK Parkinson‟s Disease Society Brain Bank Clinical Diagnosis Criteria (UKPDSBBCDC)
Healthy Control

  Eligibility

Ages Eligible for Study:   40 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

OHSU Movement Disorders Clinic Volunteers from the community (Portland, Oregon and surrounding areas)

Criteria

Inclusion Criteria:

  1. Diagnosis of probable or possible PSP as defined by the National Institute of Neurological Disorders and Stroke and Society for Progressive Supranuclear Palsy (NINDS-SPSP) diagnostic criteria.
  2. Be able to ambulate and stand unassisted for 5 minutes
  3. Be able to cooperate with gait and balance testing
  4. Be able to give informed consent.

Exclusion Criteria:

  1. Cannot exhibit behavior or have dementia that precludes participation in the protocol
  2. Cannot have medical or orthopedic illness that, in the investigator's opinion, would impact the patient's postural control or ability to participate in the study.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01563276

Contacts
Contact: Anna M Lovelace, BS, BA 503.494.9531 lovelaca@ohsu.edu
Contact: Bernadette Schoneberg, MD 503.494.7230 schonebu@ohsu.edu

Locations
United States, Oregon
Oregon Health and Science University Recruiting
Portland, Oregon, United States, 97239
Contact: Anna M Lovelace, BS, BA    503-494-9531    lovelaca@ohsu.edu   
Principal Investigator: Bernadette Schoneberg, MD         
Sponsors and Collaborators
Oregon Health and Science University
Investigators
Principal Investigator: Bernadette Schoneberg, MD Oregon Health and Science University
  More Information

Additional Information:
No publications provided

Responsible Party: Bernadette Schoneburg, Movement Disorders Fellow, Oregon Health and Science University
ClinicalTrials.gov Identifier: NCT01563276     History of Changes
Other Study ID Numbers: IRB00007924
Study First Received: March 22, 2012
Last Updated: March 23, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by Oregon Health and Science University:
Progressive Supranuclear Palsy
PSP
Falls
Gait
Balance
Parkinson's Disease
PD

Additional relevant MeSH terms:
Supranuclear Palsy, Progressive
Parkinson Disease
Paralysis
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
Ophthalmoplegia
Ocular Motility Disorders
Cranial Nerve Diseases
Tauopathies
Neurologic Manifestations
Eye Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on August 28, 2014