Change in Brain Metabolism and Cognitive Function by Aripiprazole
Dopamine receptor occupancy and brain metabolism were measured using positron emission tomography after the administration of aripiprazole. Working memory performance was also measured using N-back task.
The investigators explored the relationship between changes in brain metabolism and working memory performance.
Dopamine Receptor Occupancy
|Study Design:||Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
|Official Title:||The Relationship Between D2 Occupancy and Change in Frontal Metabolism and Working Memory Induced by Aripiprazole|
- Reaction time of correct response in N-back task [ Time Frame: 48 hrs after the administration of aripiprazole ] [ Designated as safety issue: No ]
|Study Start Date:||January 2009|
|Study Completion Date:||January 2012|
|Primary Completion Date:||May 2010 (Final data collection date for primary outcome measure)|
|Korea, Republic of|
|Seoul National University Hospital|
|Seoul, Korea, Republic of, 110-744|
|Principal Investigator:||Jun Soo Kwon, M.D., Ph.D.||Seoul National University Hospital|