Evaluation of Patients With Methicillin-Resistant Staphylococcus Aureus Hospital-Acquired Pneumonia Treated With Linezolid or Vancomycin
The objective of this study is to review the local management of patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia treated with vancomycin or linezolid with the goal to define if any difference exists among these antimicrobials in regard to clinical and economic outcomes.
Methicillin-Resistant Staphylococcus Aureus (MRSA)
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||Multicenter, Retrospective, Observational Study to Evaluate Clinical and Economic Outcomes of Patients With MRSA Hospital-Acquired Pneumonia Treated With Linezolid Or Vancomycin|
- Clinical outcomes: Cured defined as the complete resolution of signs and symptoms of pneumonia; improvement defined as a partial resolution of signs and symptoms of pneumonia; failure defined as the deterioration of signs and symptoms of pneumonia. [ Time Frame: Up to 28 days after the diagnosis of hospital-acquired pneumonia (HAP) ] [ Designated as safety issue: No ]
- Microbiological outcomes will be defined as: superinfections and colonization (positive cultures with a multi-drug resistant organism). [ Time Frame: Up to 28 days after the diagnosis of HAP ] [ Designated as safety issue: No ]
- Economic Outcomes: Calculations regarding cost of care for each study arm. [ Time Frame: Up to 28 days after the diagnosis of HAP ] [ Designated as safety issue: No ]Will be performed by obtaining the following data: length of hospital stay, length of ICU stay, duration of mechanical ventilation, duration of antimicrobial treatment, number of antibiotic free days.
|Study Start Date:||November 2008|
|Study Completion Date:||June 2013|
|Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
|Linezolid observational cohort||
Patients with documented MRSA hospital-acquired or ventilator-associated pneumonia treated with linezolid according to routine medical care.
Other Name: Zyvox
|Vancomycin observational cohort||
Patients with documented MRSA hospital-acquired or ventilator-associated pneumonia treated with vancomycin according to routine medical care.
Other Name: Vancocin
Non-randomized, retrospective, observational study