Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients
Iodine therapy is the best treatment for graves disease.Most patients receive methimozale prior to radio-iodine treatment. This may decrease treatment response to iodine therapy.
Some physicians advice to discontinue methimazole 3 days before radioiodine therapy and others prefer longer off - methimazole period which bothers most patients. This study aimed to evaluate optimum time for methimazole discontinuation in graves disease.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Treatment
- thyroid function tests over one year after radioiodine therapy [ Time Frame: months 1 , 3 ,6,9,12 ] [ Designated as safety issue: No ]thyroid function test may change over one year . In order to consider the patients as cured ,thyroid function tests should reveal hypothyroidism or euthyroidism . In order to rule out temporary hypothyroidism the tests should be repeated after 6 months of radioiodine therapy.
|Study Start Date:||February 2010|
|Study Completion Date:||January 2012|
|Primary Completion Date:||January 2012 (Final data collection date for primary outcome measure)|
Active Comparator: group one
This group will be advised to discontinue methimazole 24-48 hour before iodine therapy
Methimazole was stopped 24-48 before radio-iodine therapy
Active Comparator: group two
methimazole stopped 48-72 hour before radioiodine therapy
methimazole discontinued 49-72 hours before radioiodine treatment
|Active Comparator: group three||
methimazole discontinued 73-168 hours before radio-iodine treatment
|Iran, Islamic Republic of|
|Mashad University of Medical Sciences|
|Mashad, Khorasan Razavi, Iran, Islamic Republic of, 91766|
|Principal Investigator:||rasoul zakavi, associate professor||Mashhad University of Medical Sciences|