Influence of Tourniquet Use and Surgery Duration on the Incidence of Deep Vein Thrombosis in Total Knee Arthroplasty - Full Text View

Purpose

This is an observational study to analyze the influence of surgery duration and tourniquet time in the incidence of deep venous thrombosis (DVT) in patients that had undergone total knee arthroplasty (TKA).

Condition
Deep Vein Thrombosis

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Influence of Tourniquet Use and Surgery Duration on the Incidence of Deep Vein Thrombosis in Total Knee Arthroplasty

Resource links provided by NLM:

MedlinePlus related topics: Deep Vein Thrombosis Knee Replacement

U.S. FDA Resources

Further study details as provided by University of Sao Paulo General Hospital:

Primary Outcome Measures:

Deep vein thrombosis [ Time Frame: 7 days ] [ Designated as safety issue: No ]
Deep vein thrombosis confirmed by ascending venography performed 7 days after total knee arthroplasty.

Enrollment:	78
Study Start Date:	February 2008
Study Completion Date:	September 2011
Primary Completion Date:	June 2011 (Final data collection date for primary outcome measure)

Groups/Cohorts
ATK patients Patients from our institution that underwent cemented TKA for degenerative knee disorders.

Show Detailed Description

Eligibility

Ages Eligible for Study:	30 Years to 90 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Seventy-eight consecutive patients from our institution underwent cemented TKA for degenerative knee disorders and then underwent AV, for which they gave informed consent, at a point between 7 and 12 days after surgery, after having been discharged from the hospital.

Criteria

Inclusion Criteria:

patients that underwent cemented total knee arthroplasty

Exclusion Criteria:

post-operative infection
inadequate follow-up

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01559532

Locations

Brazil
Orthopedics Department - University of Sao Paulo General Hospital
São Paulo, Brazil, 05403-010

Sponsors and Collaborators

University of Sao Paulo General Hospital

Investigators

Study Director:

Arnaldo J Hernandez, Prof. Dr.

Orthopedics and Traumatology Department - University of Sao Paulo General Hospital

More Information

Publications:

Bergqvist D, Bergentz SE, Fredin H. Thromboembolism in orthopaedic surgery. Acta Orthop Scand. 1984 Jun;55(3):247-50.

Stringer MD, Steadman CA, Hedges AR, Thomas EM, Morley TR, Kakkar VV. Deep vein thrombosis after elective knee surgery. An incidence study in 312 patients. J Bone Joint Surg Br. 1989 May;71(3):492-7.

Caprini JA, Arcelus JI, Reyna JJ. Effective risk stratification of surgical and nonsurgical patients for venous thromboembolic disease. Semin Hematol. 2001 Apr;38(2 Suppl 5):12-9. Review.

Geerts WH, Heit JA, Clagett GP, Pineo GF, Colwell CW, Anderson FA Jr, Wheeler HB. Prevention of venous thromboembolism. Chest. 2001 Jan;119(1 Suppl):132S-175S. Review.

Haas S. Prevention of venous thromboembolism: recommendations based on the International Consensus and the American College of Chest Physicians Sixth Consensus Conference on Antithrombotic Therapy. Clin Appl Thromb Hemost. 2001 Jul;7(3):171-7. Review.

Stulberg BN, Insall JN, Williams GW, Ghelman B. Deep-vein thrombosis following total knee replacement. An analysis of six hundred and thirty-eight arthroplasties. J Bone Joint Surg Am. 1984 Feb;66(2):194-201.

Kim YH, Kim VE. Factors leading to low incidence of deep vein thrombosis after cementless and cemented total knee arthroplasty. Clin Orthop Relat Res. 1991 Dec;(273):119-24.

Haas S. Managing the risk of venous thromboembolism in orthopedics: concluding remarks. Orthopedics. 1997 Feb;20 Suppl:26-7.

Zaw HM, Osborne IC, Pettit PN, Cohen AT. Risk factors for venous thromboembolism in orthopedic surgery. Isr Med Assoc J. 2002 Nov;4(11):1040-2. Review.

Rabinov K, Paulin S. Roentgen diagnosis of venous thrombosis in the leg. Arch Surg. 1972 Feb;104(2):134-44.

Brookenthal KR, Freedman KB, Lotke PA, Fitzgerald RH, Lonner JH. A meta-analysis of thromboembolic prophylaxis in total knee arthroplasty. J Arthroplasty. 2001 Apr;16(3):293-300.

Freedman KB, Brookenthal KR, Fitzgerald RH Jr, Williams S, Lonner JH. A meta-analysis of thromboembolic prophylaxis following elective total hip arthroplasty. J Bone Joint Surg Am. 2000 Jul;82-A(7):929-38.

Lotke PA, Ecker ML, Alavi A, Berkowitz H. Indications for the treatment of deep venous thrombosis following total knee replacement. J Bone Joint Surg Am. 1984 Feb;66(2):202-8.

Wauke K, Nagashima M, Kato N, Ogawa R, Yoshino S. Comparative study between thromboembolism and total knee arthroplasty with or without tourniquet in rheumatoid arthritis patients. Arch Orthop Trauma Surg. 2002 Nov;122(8):442-6. Epub 2002 Apr 18.

Wakankar HM, Nicholl JE, Koka R, D'Arcy JC. The tourniquet in total knee arthroplasty. A prospective, randomised study. J Bone Joint Surg Br. 1999 Jan;81(1):30-3.

Responsible Party:	University of Sao Paulo General Hospital
ClinicalTrials.gov Identifier:	NCT01559532 History of Changes
Other Study ID Numbers:	222
Study First Received:	March 13, 2012
Last Updated:	March 19, 2012
Health Authority:	Brazil: Ethics Committee

Keywords provided by University of Sao Paulo General Hospital:

Deep vein thrombosis
Thromboembolism
Tourniquet
Knee prosthesis.

Additional relevant MeSH terms:

Thrombosis
Venous Thrombosis
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on May 23, 2013