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Changes in Brain Synchronization During Perceptual and Linguistic Tasks in Schizophrenic Patients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2012 by Shalvata Mental Health Center.
Recruitment status was  Not yet recruiting
Sponsor:
Collaborator:
Bar-Ilan University, Israel
Information provided by (Responsible Party):
Shalvata Mental Health Center
ClinicalTrials.gov Identifier:
NCT01550211
First received: March 7, 2012
Last updated: NA
Last verified: March 2012
History: No changes posted
  Purpose

This study aims to identify electrophysiological correlates of impaired perceptual and linguistic processes in chronic schizophrenic patients, un-medicated first-episode schizophrenic patients and their healthy relatives.

Following administrating some questionnaires (demographic details and psychiatric history questionnaire, handedness questionnaire, reading abilities test and positive and negative symptoms questionnaire) and performing a perception test and a verbal abstract intelligence test, participants will conduct a brain scan during a series of perceptual and linguistic tasks.


Condition Intervention
Schizophrenic Patients
Device: Magnetoencephalograph (MEG)

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Further study details as provided by Shalvata Mental Health Center:

Primary Outcome Measures:
  • Magnetic field amplitude and source [ Time Frame: 45 minutes ] [ Designated as safety issue: No ]

Estimated Enrollment: 150
Study Start Date: March 2012
Estimated Primary Completion Date: March 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Students
Healthy students from Bar-Ilan University
Device: Magnetoencephalograph (MEG)
Conducting a brain scan during a series of perceptual and linguistic tasks
Schizophrenic patients' relatives
Healthy family members (parents or siblings) of the schizophrenic participants (chronic and naive)
Device: Magnetoencephalograph (MEG)
Conducting a brain scan during a series of perceptual and linguistic tasks
Naive schizophrenic patients
Naive patients with a diagnosis of schizophrenia, a history of only one psychotic episode and un-medicated
Device: Magnetoencephalograph (MEG)
Conducting a brain scan during a series of perceptual and linguistic tasks
Chronic schizophrenia patients
Chronic patients with a diagnosis of schizophrenia and a history of more than one psychotic episode
Device: Magnetoencephalograph (MEG)
Conducting a brain scan during a series of perceptual and linguistic tasks

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
  1. Chronic patients - Up to 30 chronic schizophrenic patients.
  2. Naive patients - Up to 30 unmedicated first episode schizophrenic patients.
  3. Patients' relatives - Up to 60 family members (parents or siblings) of the participants - control group 1.
  4. Students - Up to 30 students from Bar-Ilan University - control group 2.
Criteria

Inclusion Criteria:

Inclusion criteria for chronic patients:

  • Hebrew native speakers.
  • Diagnosis of schizophrenia with a history of more than one episode.
  • Capable and willing to provide informed consent.

Inclusion criteria for naive patients:

  • Hebrew native speakers.
  • Diagnosis of schizophrenia with a history of only one episode and unmedicated.
  • Capable and willing to provide informed consent.

Inclusion criteria for patients' relatives (control group 1):

  • Hebrew native speakers.
  • Without any psychiatric history.
  • Have a child and/or a sibling with schizophrenia.

Inclusion Criteria for students (control group 2):

  • Hebrew native speakers.
  • Without any psychiatric history.

Exclusion Criteria:

Exclusion Criteria for patient groups (chronic and "naïve"):

  • Left handedness.
  • Reading disability.
  • Visual perception disability.
  • Brain damage and/or a history of seizures.
  • Impaired intelligence.
  • Metal implants.

Exclusion Criteria for control groups (family members and students):

  • Psychiatric history.
  • Left handedness.
  • Reading disability.
  • Visual perception disability.
  • Brain damage and/or a history of seizures.
  • Impaired intelligence.
  • Metal implants.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01550211

Contacts
Contact: Maor Zeev-Wolf, M.A. 972-50-7737032 maorwolf@gmail.com

Locations
Israel
Shalvata MHC Not yet recruiting
Hod-Hasharon, Israel
Contact: Maor Zeev-Wolf, M.A.    972-50-7737032    maorwolf@gmail.com   
Sub-Investigator: Maor Zeev-Wolf, M.A.         
Sponsors and Collaborators
Shalvata Mental Health Center
Bar-Ilan University, Israel
Investigators
Principal Investigator: Hilik Levkovitz, Professor Shalvata MHC
  More Information

No publications provided

Responsible Party: Shalvata Mental Health Center
ClinicalTrials.gov Identifier: NCT01550211     History of Changes
Other Study ID Numbers: SHA-0001-12
Study First Received: March 7, 2012
Last Updated: March 7, 2012
Health Authority: Israel: Ministry of Health

ClinicalTrials.gov processed this record on November 25, 2014