Free Fatty Acids: Threshold Repeatability Study
This study seeks to determine if non-esterified fatty acid (NEFA) taste detection thresholds change with repeated testing. Threshold testing for NEFA taste has been reported by a number of laboratories, including our own; however, these studies have reported data for only one testing occasion. The investigators seek to conduct repeated testing to measure the test-retest reliability of these methods. The investigators believe that with repeated exposure to NEFA, a person's sensitivity increases. The investigators are also testing the efficiency of testing by two methods (forced-choice ascending trial versus staircase). Additionally, the association between taste responses, diet and BMI will be explored.
Taste, Non-esterified Fatty Acids
|Study Design:||Observational Model: Case-Crossover
Time Perspective: Prospective
|Official Title:||Free Fatty Acids: Threshold Repeatability Study|
- Non-esterified fatty acid detection thresholds in humans [ Time Frame: 6 months ] [ Designated as safety issue: No ]
- BMI [ Time Frame: Baseline ] [ Designated as safety issue: No ]
- Habitual fat intake [ Time Frame: Baseline ] [ Designated as safety issue: No ]Block Rapid Dietary Fat Screener will be used as well as the ASA-24.
- testing method [ Time Frame: 6 months ] [ Designated as safety issue: No ]Comparison of time to maximum sensitivity by participants based on forced-choice versus staircase stimulus presentation techniques.
- hunger [ Time Frame: each visit ] [ Designated as safety issue: No ]Visual analog scale
|Study Start Date:||March 2012|
|Study Completion Date:||November 2013|
|Primary Completion Date:||November 2013 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01550120
|United States, Indiana|
|West Lafayette, Indiana, United States, 47907|
|Principal Investigator:||Richard D Mattes, PhD||Purdue University|