Understanding the Physiological Implications of Scanning Kelvin Probe Measurements
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Purpose
The purpose of this study is to evaluate the effects of skin thickness, skin moisture, and sweat gland density on Scanning Kelvin Probe measurements.
| Condition | Intervention |
|---|---|
|
Healthy Individuals Skin Electrical Potential |
Other: Skin Moistening, Skin Denuding |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Measuring Skin Electrical Potential With the Kelvin Probe: Underlying Physiology |
- Surface Electrical Potential [ Time Frame: 1 day ] [ Designated as safety issue: No ]The electrical potential of skin obtained from the Scanning Kelvin Probe
- Electrical Impedance [ Time Frame: One day ] [ Designated as safety issue: No ]Electrical impedance (measurement) obtained through another, more conventional measurement device.
Biospecimen Retention: Samples With DNA
Whole Blood
| Estimated Enrollment: | 24 |
| Study Start Date: | August 2011 |
| Estimated Study Completion Date: | August 2012 |
| Estimated Primary Completion Date: | August 2012 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
Healthy Volunteers
Human subjects without chronic medical conditions, defined as conditions requiring chronic medication use.
|
Other: Skin Moistening, Skin Denuding
Application of normal saline to skin and Tape stripping of the superficial skin
|
Detailed Description:
The Scanning Kelvin Probe measures the electrical potential of material surfaces without actually touching it. Although this technology has been applied to non-living materials (e.g. metal and semiconductors) before, it has not been effectively applied to biological materials, much less to live human skin . This project aims to evaluate the use of Scanning Kelvin Probe to live human skin by investigating the effects of skin thickness, skin moisture, and sweat glands on Kelvin Probe measurements of electrical potential. Testing will be performed on the arms and hands of twenty four healthy individuals under different study conditions.
Eligibility| Ages Eligible for Study: | 18 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
Healthy Volunteers
Inclusion Criteria:
- "Healthy" is defined as not having a chronic medical condition requiring daily medications (hypertension, diabetes, hypothyroidism, etc)
Exclusion Criteria:
- autonomic disorders (sweating irregularities), skin disorders, extensive burns/scars on the hand, tremors, neuromuscular conditions, restless leg syndrome, movement disorders, and implanted cardiac defibrillator/pacemaker
Contacts and Locations| United States, Massachusetts | |
| Massachusetts General Hospital - Martinos Center for Biomedical Imaging | |
| Charlestown, Massachusetts, United States, 02129 | |
| Principal Investigator: | Andrew C. Ahn, MD, MPH | Massachusetts General Hospital |
More Information
No publications provided
| Responsible Party: | Andrew A. Ahn, Assistant Professor, Massachusetts General Hospital |
| ClinicalTrials.gov Identifier: | NCT01545973 History of Changes |
| Other Study ID Numbers: | 55R21AT005249-02 |
| Study First Received: | March 2, 2012 |
| Last Updated: | March 2, 2012 |
| Health Authority: | United States: Institutional Review Board |
ClinicalTrials.gov processed this record on May 23, 2013