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Sensory Stimulation Effect on Movement Speed in Patients With Parkinson Disease

This study has been completed.
Sponsor:
Collaborators:
Belgium: Belgian National Fund for Scientific Research (FNRS)
Belgium: Belgian Federal Science Policy Office (BELSPO)
Information provided by (Responsible Party):
Ana Bengoetxea, Université Libre de Bruxelles
ClinicalTrials.gov Identifier:
NCT01544738
First received: February 23, 2012
Last updated: March 5, 2012
Last verified: February 2012
  Purpose

Movement slowness (bradykinesia) is one of the main motor symptoms in Parkinson Disease (PD). Several studies have shown that patients with PD exhibit slowness because they are unable to modulate, in an optimal way, the velocity of voluntary motor acts not induced by external stimulation. Indeed, these patients have difficulties to integrate multi-sensorial information, mainly proprioception.

The investigators investigated changes in shoulder velocity during pointing movements by patients with PD after stimulation of soft tissues (aponeurosis) of upper limb muscles. The stimulation consisted of manipulating, with a hook (the diacutaneous fibrolysis method), the aponeurotic tissues enrobing the heads of the upper limb muscles. This technique has previously been shown to decrease passive tension and the tendon reflex response of the manipulated muscle group. The investigators hypothesis is that aponeurotic manipulation of shoulder muscles therefore creates a modification in the proprioceptive information, which in return temporarily decreases the bradykinesia of shoulder movements.


Condition Intervention
Parkinson Disease
Other: Aponeurotic stimulation (the diacutaneous fibrolysis method)
Other: Placebo stimulation

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
Official Title: Aponeurotic Stimulation Effect on Parkinson Bradykinesia

Resource links provided by NLM:


Further study details as provided by Université Libre de Bruxelles:

Primary Outcome Measures:
  • 3D kinematic movement parameters and upper limb muscles electromyographic activation [ Time Frame: Participants will be followed for the duration of the clinical test (2 weeks) ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Unified Parkinson's Disease Rating Scale (UPDRS) [ Time Frame: Participants will be followed for the duration of the clinical test (2 weeks) ] [ Designated as safety issue: No ]

Enrollment: 11
Study Start Date: November 2008
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Aponeurotic stimulation group
The stimulation consisted of manipulating, with a hook (the diacutaneous fibrolysis method), the aponeurotic tissues enrobing the heads of the trunk and upper limb muscles.
Other: Aponeurotic stimulation (the diacutaneous fibrolysis method)
Treatment consisted of manipulating, with a hook, the aponeurotic tissues enrobing the heads of the upper-limb muscles. The manipulation consisted of back and forth mobilization, applied perpendicularly to the axis of the muscular fibers. The mobilization is performed with both hands; the therapist's non-dominant hand performs a manual mobilization whereas the dominant hand follows the movement with the hook. The hook allows the therapist to be very precise about the location of the tissues that are stretched. This stretch is realized at the level of the aponeurotic fibers presenting the greatest resistance to perpendicular movement. The shape of the hook is chosen to avoid discomfort or pain during manipulation. To spread the pressure exerted by the spatula on a very local point, it is important to fill completely the curved part of the hook with the adjacent soft tissues. We manipulated muscle from the proximal insertion towards the distal, giving special attention to the tendons.
Active Comparator: Placebo stimulation group
Placebo stimulation (PS) consisted of manipulating the skin along the same paths over the trunk, shoulder and arm muscles that were the targets for treatment in the Aponeurotic stimulation group.
Other: Placebo stimulation
Placebo stimulation (PS) consisted of manipulating the skin along the same paths over the trunk, shoulder and arm muscles that were the targets for treatment in the AS group

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Clinical diagnosis of Parkinson Disease

Exclusion Criteria:

  • Patients with a limitation in the shoulder range of motion necessary to perform pointing movements
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01544738

Locations
Belgium
ULB-FSM Laboratory of neurophysiology and movement biomechanics
Brussels, Belgium, 1070
Sponsors and Collaborators
Université Libre de Bruxelles
Belgium: Belgian National Fund for Scientific Research (FNRS)
Belgium: Belgian Federal Science Policy Office (BELSPO)
Investigators
Principal Investigator: Ana Bengoetxea, PhD Université Libre de Bruxelles
Study Chair: Françoise Leurs, PhD Student Université Libre de Bruxelles
Study Chair: Leslie Rigal, Master Student Université Libre de Bruxelles
Study Director: Guy Cheron, PhD Université Libre de Bruxelles
  More Information

No publications provided

Responsible Party: Ana Bengoetxea, Assistant Professor, Université Libre de Bruxelles
ClinicalTrials.gov Identifier: NCT01544738     History of Changes
Other Study ID Numbers: LMNB-01
Study First Received: February 23, 2012
Last Updated: March 5, 2012
Health Authority: Belgium: Ministry of Social Affairs, Public Health and the Environment

Keywords provided by Université Libre de Bruxelles:
Parkinson Disease
sensory stimulation
Bradykinesia

Additional relevant MeSH terms:
Parkinson Disease
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Movement Disorders
Nervous System Diseases
Neurodegenerative Diseases
Parkinsonian Disorders

ClinicalTrials.gov processed this record on November 27, 2014