MR-Evaluation of Renal Function-After-Pancreas-transplantation (MERFAP)

This study is not yet open for participant recruitment.
Verified February 2012 by Uppsala University
Information provided by (Responsible Party):
Per Liss, Uppsala University Identifier:
First received: February 13, 2012
Last updated: February 22, 2012
Last verified: February 2012

The purpose of this study is to evaluate the beneficial effect of pancreas transplantation for long term kidney function in patients undergoing single-pancreas transplantation.

Renal Failure
Pancreas Transplantation

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: MR-Evaluation of Renal Function-After-Pancreas-transplantation

Resource links provided by NLM:

Further study details as provided by Uppsala University:

Primary Outcome Measures:
  • Kidney function [ Time Frame: Within 3 years ] [ Designated as safety issue: No ]
    Improvements in kidney function (GFR) and proteinuria after pancreas transplantation.

Secondary Outcome Measures:
  • Kidney hemodynamics and oxygenation [ Time Frame: Within 3 years ] [ Designated as safety issue: No ]
    Improvements in renal blood flow and kidney tissue oxygenation after pancreas transplantation.

Estimated Enrollment: 40
Study Start Date: February 2012
Estimated Study Completion Date: August 2015
Estimated Primary Completion Date: February 2015 (Final data collection date for primary outcome measure)
Patients with pancreastransplantation
All patients undergoing pancreas transplantation.

Detailed Description:

Renal failure in patients who have performed a pancreas transplantation is a hazard for the outcome for these patients. The beneficial effect of pancreas transplantation for renal function is not clear. It is of major importance to early find patients who develops a decrease in renal function and start treatment early and closely monitor these patients in order to avoid further deteriorating renal function. In order to achieve this, there is a need for a easy, fast and sensitive method to evaluate renal function. In this study the investigators plan to use the non-invasive MR to evaluate changes in renal function.


Ages Eligible for Study:   15 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with diabetes mellitus


Inclusion Criteria:

  • Patients with diabetes mellitus
  • Patients undergoing a pancreas transplantation

Exclusion Criteria:

  • Patients undergoing a pancreas transplantation and a renal transplantation at the same time.
  Contacts and Locations
Please refer to this study by its identifier: NCT01537445

University Hospital Not yet recruiting
Uppsala, Sweden, 75185
Contact: Per Liss, MD, PhD.    +46186110000   
Sponsors and Collaborators
Uppsala University
Study Director: Per Liss, MD, PhD. Uppsala University, Uppsala, Sweden
  More Information

No publications provided

Responsible Party: Per Liss, Associate professor, Uppsala University Identifier: NCT01537445     History of Changes
Other Study ID Numbers: MERFAP-2012
Study First Received: February 13, 2012
Last Updated: February 22, 2012
Health Authority: Sweden: Regional Ethical Review Board

Keywords provided by Uppsala University:
Diabetes Mellitus
Renal failure

Additional relevant MeSH terms:
Diabetes Mellitus
Renal Insufficiency
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Kidney Diseases
Urologic Diseases
Gastrointestinal Agents
Therapeutic Uses
Pharmacologic Actions processed this record on April 15, 2014