Making Memory Better for Seniors With Mild Cognitive Impairment

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by Capital District Health Authority, Canada
Sponsor:
Collaborator:
Nova Scotia Health Research Foundation
Information provided by (Responsible Party):
Capital District Health Authority, Canada
ClinicalTrials.gov Identifier:
NCT01532739
First received: February 10, 2012
Last updated: March 12, 2014
Last verified: March 2014
  Purpose

The purpose of this study is to investigate the feasibility and effectiveness of a cognitive training group in individuals with Mild Cognitive Impairment, using a new paradigm that will optimize ecological validity by (1) focusing on everyday memory problems, (2) supplementing traditional memory training with the teaching of an empirically-supported problem-solving approach, and (3) employing a clinically representative sample of individuals with MCI (e.g., not excluding those with mild affective symptoms).


Condition Intervention
Mild Cognitive Impairment
Behavioral: Cognitive training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Neuropsychological Intervention for a Seniors Mental Health Population With Mild Cognitive Impairment

Resource links provided by NLM:


Further study details as provided by Capital District Health Authority, Canada:

Primary Outcome Measures:
  • Change in everyday memory functioning [ Time Frame: Measured at baseline and months 3, 5, 8 ] [ Designated as safety issue: No ]
    Rivermead Behavioural Memory Test (3rd Edition)


Secondary Outcome Measures:
  • Change on traditional memory testing [ Time Frame: Measured at baseline and months 3, 5, 8 ] [ Designated as safety issue: No ]
    California Verbal Learning Test (2nd Edition)

  • Change in memory perception [ Time Frame: Measured at baseline and months 3, 5, 8 ] [ Designated as safety issue: No ]
    Multifactorial Metamemory Questionnaire

  • Change in mood (i.e., self-report symptoms of depression) [ Time Frame: Measured at baseline and months 3, 5, 8 ] [ Designated as safety issue: No ]
    Geriatric Depression Scale

  • Change in mood (i.e., self-report symptoms of anxiety) [ Time Frame: Measured at baseline and months 3, 5, 8 ] [ Designated as safety issue: No ]
    Beck Anxiety Inventory

  • Change in other psychiatric symptoms (informant-report) [ Time Frame: Measured at baseline and months 3, 5, 8 ] [ Designated as safety issue: No ]
    Neuropsychiatric Inventory

  • Change in quality of life [ Time Frame: Measured at baseline and months 3, 5, 8 ] [ Designated as safety issue: No ]
    Zarit Burden Interview

  • Change in caregiver burden [ Time Frame: Measured at baseline and months 3, 5, 8 ] [ Designated as safety issue: No ]
    Zarit Burden Interview

  • Feasibility [ Time Frame: Measured at end of study ] [ Designated as safety issue: No ]
    Recruitment, retention, and compliance rates


Estimated Enrollment: 40
Study Start Date: April 2012
Estimated Primary Completion Date: April 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cognitive training Behavioral: Cognitive training
The cognitive training consists of 10 weekly 2-hour sessions. It is run with groups of MCI participants and their study partners (who help with reinforcing the strategies in everyday activities). The program provides information about memory and lifestyle factors in the first two weeks, followed by training and practice over the next eight weeks on empirically-supported cognitive strategies known to be effective at supporting day-to-day remembering in MCI. Participants learn to apply a core set of strategies (spaced retrieval, memory book logging) across a variety of common memory problems (e.g., remembering names, appointments, etc). To enhance the likelihood that these strategies will transfer to other settings beyond training, participants are also taught a memory problem solving approach that will cue them to recognize situations in which they need to: (1) stop and remember something, (2) select and apply an appropriate memory strategy, and (3) monitor that it is working.
No Intervention: No cognitive training

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Clinical diagnosis of Mild Cognitive Impairment

Exclusion Criteria:

  • Clinical diagnosis of dementia
  • History of neurological conditions known to impair cognition
  • History of alcohol or drug abuse
  • History of chronic psychiatric illness
  • Current symptoms of moderate to severe depression (Geriatric Depression Scale >19) or anxiety (Beck Anxiety Inventory >15)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01532739

Contacts
Contact: Karen A Chipman, PhD 902-464-6059 karen.chipman@cdha.nshealth.ca

Locations
Canada, Nova Scotia
Neuropsychology Service, Nova Scotia Hospital Recruiting
Dartmouth, Nova Scotia, Canada, B2Y 3Z9
Contact: Karen A Chipman, PhD    902-464-6059    karen.chipman@cdha.nshealth.ca   
Principal Investigator: Karen A Chipman, PhD         
Sponsors and Collaborators
Capital District Health Authority, Canada
Nova Scotia Health Research Foundation
Investigators
Principal Investigator: Karen A Chipman, PhD Capital District Health Authority, Canada
  More Information

No publications provided

Responsible Party: Capital District Health Authority, Canada
ClinicalTrials.gov Identifier: NCT01532739     History of Changes
Other Study ID Numbers: CDHA-RS/2012-227
Study First Received: February 10, 2012
Last Updated: March 12, 2014
Health Authority: Canada: Ethics Review Committee

Keywords provided by Capital District Health Authority, Canada:
Mild Cognitive Impairment
Aging
Memory
Executive Function
Cognitive Intervention
Memory Training
Mental Health

Additional relevant MeSH terms:
Mild Cognitive Impairment
Cognition Disorders
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on September 22, 2014